Protein Information

Name glycogen synthase kinase 3
Synonyms GSK 3 beta; GSK3 beta; GSK3B; GSK3B protein; Glycogen synthase kinase 3 beta; GSK3 betas; GSK3B proteins; Glycogen synthase kinase 3 betas…

Compound Information

Name kinetin
CAS

Reference List

PubMed Abstract RScore(About this table)
10419627 Peterson MF, Martin WH, Spencer RW, Tate BF: The use of beta, gamma-methyleneadenosine 5'-triphosphate to determine ATP competition in a scintillation proximity kinase assay. Anal Biochem. 1999 Jul 1;271(2):131-6.


This method uses glycogen synthase kinase beta as the model protein kinase and looks at the shift in IC50 of inhibitors using the nonhydrolyzable ATP analog, beta, gamma-methyleneadenosine 5'-triphosphate, also known as AMP-PCP.
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9271202 Munoz-Montano JR, Moreno FJ, Avila J, Diaz-Nido J: Lithium inhibits Alzheimer's disease-like tau protein phosphorylation in neurons. FEBS Lett. 1997 Jul 14;411(2-3):183-8.


Now we report that lithium (an inhibitor of glycogen synthase kinase-3) causes tau dephosphorylation at the sites recognized by antibodies Tau-1 and PHF-1 both in cultured neurons and in vivo in rat brain.
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12534346 Bain J, McLauchlan H, Elliott M, Cohen P: The specificities of protein kinase inhibitors: an update. Biochem J. 2003 Apr 1;371(Pt 1):199-204.


Our results suggest that the combined use of Roscovitine and Kenpaullone may be useful for identifying substrates and physiological roles of cyclin-dependent protein kinases, whereas the combined use of Kenpaullone and LiCl may be useful for identifying substrates and physiological roles of glycogen synthase kinase 3.
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15152189 Morfini G, Szebenyi G, Brown H, Pant HC, Pigino G, DeBoer S, Beffert U, Brady ST: A novel CDK5-dependent pathway for regulating GSK3 activity and kinesin-driven motility in neurons. EMBO J. 2004 Jun 2;23(11):2235-45. Epub 2004 May 20.


This pathway involves enzymatic activities of cyclin-dependent kinase 5 (CDK5), protein phosphatase 1 (PP1) and glycogen synthase kinase-3 (GSK3).
1(0,0,0,1) Details