Protein Information

Name lactate dehydrogenase (protein family or complex)
Synonyms LDH; lactate dehydrogenase; lactate dehydrogenases

Compound Information

Name methidathion
CAS

Reference List

PubMed Abstract RScore(About this table)
2865066 Asztalos B, Nemcsok J: Effect of pesticides on the LDH activity and isoenzyme pattern of carp (Cyprinus carpio L.) sera. Comp Biochem Physiol C. 1985;82(1):217-9.

Copper sulphate (CuSO4), paraquat (PQ) and methidathion (MD) all caused tissue necrosis as demonstrated by increased levels of lactate dehydrogenase (LDH, EC 1.1.1.27) in blood sera.
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2322021 Asztalos B, Nemcsok J, Benedeczky I, Gabriel R, Szabo A, Refaie OJ: The effects of pesticides on some biochemical parameters of carp (Cyprinus carpio L.). Arch Environ Contam Toxicol. 1990 Mar-Apr;19(2):275-82.

Treatments with copper sulphate (CuSO4), paraquat (PQ) and methidathion (MD) caused tissue damage and stress effects in carp, indicated by the increased lactate dehydrogenase (LDH), glutamic oxaloacetic transaminase (GOT), and glutamate dehydrogenase (GIDH) enzyme activities and elevated blood-sugar levels.
6(0,0,1,1) Details
3448863 Nemcsok J, Asztalos B, Vig E, Orban L: The effect of an organophosphorus pesticide on the enzymes of carp (Cyprinus carpio L.). Acta Biol Hung. 1987;38(1):77-85.


The effect of 1.5, 2.0 and 5.0 ppm methidation was studied on the ASAT, ALAT, LDH and AChE enzymes, as well as the blood sugar and adrenaline levels in carp. 2.
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12185416 Altuntas I, Delibas N, Demirci M, Kilinc I, Tamer N: The effects of methidathion on lipid peroxidation and some liver enzymes: role of vitamins E and C. Arch Toxicol. 2002 Aug;76(8):470-3. Epub 2002 May 29.

The activities of aspartate aminotransferase (AST), alkaline phosphatase (ALP), gamma-glutamyltransferase (GGT) and lactate dehydrogenase (LDH) were increased in both the MD and MD+Vit groups compared with the control group.
1(0,0,0,1) Details
16583303 Sutcu R, Altuntas I, Yildirim B, Karahan N, Demirin H, Delibas N: The effects of subchronic methidathion toxicity on rat liver: role of antioxidant vitamins C and E. Cell Biol Toxicol. 2006 May;22(3):221-7.

The serum activities of cholinesterase (ChE), alanine transferase (ALT), aspartate amiotransferase (AST), lactate dehydrogenase (LDH), gamma-glutamyltransferase (GGT), alkaline phosphatase (ALP), and the concentration of malondialdehyde (MDA) and liver histopathology were studied.
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3591163 Asztalos B: LDH enzymes as a tool on monitoring tissue necrosis in fishes caused by pesticides. Acta Biol Hung. 1986;37(1):59-65.

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