Protein Information

Name Met protein
Synonyms HGF receptor; HGF/SF receptor; HGFR; Hepatocyte growth factor receptor; Hepatocyte growth factor receptor precursor; MET; MET protein; Met proto oncogene tyrosine kinase…

Compound Information

Name methoprene
CAS

Reference List

PubMed Abstract RScore(About this table)
9501163 Ashok M, Turner C, Wilson TG: Insect juvenile hormone resistance gene homology with the bHLH-PAS family of transcriptional regulators. Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):2761-6.

Transformation of Met flies with a Met+ cDNA resulted in susceptibility to methoprene, indicating that the cDNA encodes a functional Met+ protein.
6(0,0,1,1) Details
20018242 Zhu J, Busche JM, Zhang X: Identification of juvenile hormone target genes in the adult female mosquitoes. Insect Biochem Mol Biol. 2010 Jan;40(1):23-9. Epub 2009 Dec 16.

The observed upregulations can be also induced by the JH analogues, methoprene and pyriproxyfen, but not by farnesol, indicating that these responses are JH-specific.
We found that the upregulation of AaKr-h1 after eclosion relied on the function of the mosquito Met protein, suggesting that a conserved JH signaling pathway is utilized both in the metamorphosis of T. castaneum and in the adult reproductive maturation of the Aedes aegypti mosquito.
1(0,0,0,1) Details
18980211 Bitra K, Palli SR: Interaction of proteins involved in ecdysone and juvenile hormone signal transduction. Arch Insect Biochem Physiol. 2009 Feb;70(2):90-105.


An 85 kDa protein identified in Drosophila melanogaster methoprene-tolerant (Met) mutant binds to JH III with high affinity, and the mutant flies are resistant to juvenile hormone analog (JHA), methoprene.
0(0,0,0,0) Details
12770209 Gruntenko NE, Khlebodarova TM, Vasenkova IA, Sukhanova MJ, Wilson TG, Rauschenbach IY: Stress-reactivity of a Drosophila melanogaster strain with impaired juvenile hormone action. J Insect Physiol. 2000 Apr;46(4):451-456.


Met (27) is a null allele of the Methoprene-tolerant gene of D. melanogaster that shows resistance to the toxic effects of both juvenile hormone (JH) and a JH analog, methoprene.
0(0,0,0,0) Details