Protein Information

Name Cytochrome c oxidase (protein family or complex)
Synonyms COX; cytochrome c oxidase; cytochrome c oxidases

Compound Information

Name methoprene
CAS

Reference List

PubMed Abstract RScore(About this table)
18678927 Mamatha DM, Kanji VK, Cohly HH, Rao MR: Juvenile Hormone Analogues, methoprene and fenoxycarb dose-dependently enhance certain enzyme activities in the silkworm Bombyx mori (L). Int J Environ Res Public Health. 2008 Jun;5(2):120-4.

Methoprene and fenoxycarb at doses of 1.0 microg and 3.0 fg/larvae/48 hours showed enhancement of the 5th instar B. mori larval muscle and silkgland protease, aspartate aminotransaminase (AAT) and alanine aminotransaminase (ALAT), adenosine triphosphate synthase (ATPase) and cytochrome-c-oxidase (CCO) activity levels, indicating an upsurge in the overall oxidative metabolism of the B.mori larval tissues.
31(0,1,1,1) Details
17499267 Singtripop T, Saeangsakda M, Tatun N, Kaneko Y, Sakurai S: Correlation of oxygen consumption, cytochrome c oxidase, and cytochrome c oxidase subunit I gene expression in the termination of larval diapause in the bamboo borer, Omphisa fuscidentalis. J Insect Physiol. 2007 Sep;53(9):933-9. Epub 2007 Mar 15.

Topical application of methoprene, a juvenile hormone analog (JHA), to diapausing larvae terminated the diapause and was associated with an increase in O (2) consumption rate at diapause termination.
4(0,0,0,4) Details
11800016 Farkas R, Sut'akova G: Swelling of mitochondria induced by juvenile hormone in larval salivary glands of Drosophila melanogaster. Biochem Cell Biol. 2001;79(6):755-64.

Morphological change of mitochondria and about a fivefold increase in cytochrome c oxidase activity in response to juvenile hormone appear to be a consequence of uncoupling of oxidative phosphorylation.
We have noticed no significant difference of the responses in Methoprene, the juvenile hormone resistant mutant, suggesting that this action of juvenile hormone may be mediated via a mechanism different from that using nuclear transcription factors.
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18511104 Monteiro JP, Oliveira PJ, Moreno AJ, Jurado AS: Disruption of hepatic mitochondrial bioenergetics is not a primary mechanism for the toxicity of methoprene - relevance for toxicological assessment. Chemosphere. 2008 Jul;72(9):1347-54. Epub 2008 Jun 3.

0(0,0,0,0) Details