| Name | RXRalpha |
|---|---|
| Synonyms | NR2B1; RXR alpha; RXRA; RXRalpha; Retinoic acid receptor RXR alpha; Retinoid X receptor alpha; RXR alphas; RXRalphas… |
| Name | methoprene |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 14691372 | Pinaire J, Chou WY, Morton M, You M, Zeng Y, Cho WK, Galli A, Everett L, Breen H, Dumaual N, Smith JR, Crabb D: Identification of a retinoid receptor response element in the human aldehyde dehydrogenase-2 promoter. Alcohol Clin Exp Res. 2003 Dec;27(12):1860-6. This was confirmed in the case of RXRalpha using the RXR-specific ligand methoprene. |
82(1,1,1,2) | Details |
| 15583048 | Brandebourg TD, Hu CY: Regulation of differentiating pig preadipocytes by . J Anim Sci. 2005 Jan;83(1):98-107. Addition of methoprene acid, an RXR-specific agonist, increased (P < 0.01) GPDH activity. Addition of TTNPB decreased (P < 0.001) the expression of peroxisome proliferator-activated receptor gamma (PPARgamma), sterol regulatory element-binding protein-1c (SREBP-1c), retinoid X receptor alpha (RXRalpha), and adipocyte fatty acid binding protein (aP2) mRNA transcripts, whereas these effects were prevented by the presence of Ro-61. |
2(0,0,0,2) | Details |
| 10600643 | Alvarez R, Checa M, Brun S, Vinas O, Mampel T, Iglesias R, Giralt M, Villarroya F: Both -receptor- and retinoid-X-receptor-dependent signalling pathways mediate the induction of the brown-adipose-tissue-uncoupling-protein-1 gene by retinoids. Biochem J. 2000 Jan 1;345 Pt 1:91-7. Either RAR-specific inverted question markp-[(E)-2-(5,6,7,8,-tetrahydro-5,5,8, 8-tetramethyl-2-naphthalenyl)-1-propenyl] inverted question mark or RXR-specific [isopropyl-(E,E)-(R,S)-11-methoxy-3,7, 11-trimethyldodeca-2,4-dienoate, or methoprene] synthetic compounds increase the expression of UCP-1 mRNA and the activity of chloramphenicol acetyltransferase expression vectors driven by the ucp-1 promoter. During brown-adipocyte differentiation RXRalpha and RXRgamma mRNA expression is induced in parallel with UCP-1 mRNA, whereas the mRNA for the three RAR subtypes, alpha, beta and gamma, decreases. |
2(0,0,0,2) | Details |