| Name | Lactoferrin |
|---|---|
| Synonyms | GIG12; Growth inhibiting protein 12; HLF 2; HLF2; LF; LTF; Lactoferrin; Lactotransferrin… |
| Name | methoxychlor |
|---|---|
| CAS | 1,1′-(2,2,2-trichloroethylidene)bis[4-methoxybenzene] |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11908639 | Zhang Z, Teng CT: Methoxychlor stimulates the mouse lactoferrin gene promoter through a GC-rich element. Biochem Cell Biol. 2002;80(1):23-6. Constructs that contain a mouse lactoferrin 5' region longer than 100 bp were activated more than twofold by both methoxychlor and HPTE. |
126(1,2,4,6) | Details |
| 10433208 | Ghosh D, Taylor JA, Green JA, Lubahn DB: Methoxychlor stimulates -responsive messenger ribonucleic acids in mouse uterus through a non-estrogen receptor (non-ER) alpha and non-ER beta mechanism. Endocrinology. 1999 Aug;140(8):3526-33. This study examined the effects of the xenoestrogen methoxychlor (Mxc) on messenger RNA (mRNA) concentrations of two -responsive uterine genes, lactoferrin (LF) and glucose-6-phosphate dehydrogenase (G6PD). |
6(0,0,1,1) | Details |
| 10828501 | Mehmood Z, Smith AG, Tucker MJ, Chuzel F, Carmichael NG: The development of methods for assessing the in vivo oestrogen-like effects of xenobiotics in CD-1 mice. Food Chem Toxicol. 2000 Jun;38(6):493-501. We have conducted dose response studies in immature (21 days old) CD-1 female mice treated with four compounds, diethylstilboestrol (DES) (0.1 microg to 25 mg/kg body weight), alpha-zearalanol (0.5 mg to 25 mg/kg body weight), methoxychlor (0.5 mg to 500 mg/kg body weight) and bisphenol A (10 microg to 100 mg/kg body weight) administered subcutaneously daily for 3 days, and measured a number of uterine markers in treated and control (vehicle treated) mice. These were, in addition to the commonly measured changes in relative uterus weight and histopathological examination of uterine tissue, three other markers indicative of uterotrophic effects, namely, uterine luminal epithelium BrdU labelling index over the last 24 hr, peroxidase activity and lactoferrin expression. |
2(0,0,0,2) | Details |
| 16324804 | Andersen HR, Bonefeld-Jorgensen EC, Nielsen F, Jarfeldt K, Jayatissa MN, Vinggaard AM: Estrogenic effects in vitro and in vivo of the fungicide fenarimol. Toxicol Lett. 2006 May 25;163(2):142-52. Epub 2005 Dec 1. In addition, mRNA levels of the responsive gene lactoferrin (LF) were decreased in uteri, serum FSH levels were increased, and T3 levels decreased in fenarimol-treated animals. To our knowledge, only two other pesticides (o,p-DDT and methoxychlor) have previously been reported to induce an estrogenic response in the rodent uterotrophic bioassay. |
1(0,0,0,1) | Details |
| 11390168 | Newbold RR, Jefferson WN, Padilla-Banks E, Walker VR, Pena DS: Cell response endpoints enhance sensitivity of the immature mouse uterotropic assay. Reprod Toxicol. 2001 May-Jun;15(3):245-52. Outbred immature CD-1 mice were subcutaneously (s.c.) injected once on postnatal day 17 or on postnatal days 17, 18, and 19 with 17beta- diethylstilbestrol, tamoxifen, 4-hydroxytamoxifen, methoxychlor, the methoxychlor metabolite HPTE, nonylphenol, o,p'-DDT, endosulfan, or kepone over a wide dose range (0.1 to 1,000,000 microg/kg). Choosing the maximum wet weight dose for each compound, uterine tissue was evaluated for epithelial cell height, epithelial and stromal cell proliferation, endometrial gland number, and induction of -inducible proteins lactoferrin and complement C3. |
1(0,0,0,1) | Details |