Protein Information

Name CREB
Synonyms Active transcription factor CREB; CREB; CREB 1; CREB1; cAMP response element binding protein; cAMP response element binding protein 1; cAMP responsive element binding protein 1; cAMP responsive element binding protein 1 isoform B…

Compound Information

Name methoxychlor
CAS 1,1′-(2,2,2-trichloroethylidene)bis[4-methoxybenzene]

Reference List

PubMed Abstract RScore(About this table)
16177237 Schuh RA, Kristian T, Gupta RK, Flaws JA, Fiskum G: Methoxychlor inhibits brain mitochondrial respiration and increases hydrogen peroxide production and CREB phosphorylation. Toxicol Sci. 2005 Dec;88(2):495-504. Epub 2005 Sep 21.
82(1,1,1,2) Details
11908639 Zhang Z, Teng CT: Methoxychlor stimulates the mouse lactoferrin gene promoter through a GC-rich element. Biochem Cell Biol. 2002;80(1):23-6.

Whether the effect of methoxychlor requires the AP1/CREB binding element has yet to be established; however, the present finding provides an alternative signaling pathway for the xenoestrogens.
32(0,1,1,2) Details