Protein Information

Name glutathione S transferase
Synonyms GST class alpha 2; Gst2; GST class alpha; GST class alpha member 2; GST gamma; GSTA 2; GSTA2; GSTA2 2…

Compound Information

Name methoxychlor
CAS 1,1′-(2,2,2-trichloroethylidene)bis[4-methoxybenzene]

Reference List

PubMed Abstract RScore(About this table)
15110472 Hoarau P, Garello G, Gnassia-Barelli M, Romeo M, Girard JP: Effect of three xenobiotic compounds on Glutathione S-Transferase in the clam Ruditapes decussatus. Aquat Toxicol. 2004 May 28;68(1):87-94.

The effects of 4,4'DDE, methoxychlor and imidazole were studied on glutathione S-transferase activities in the gills and hepatopancreas of the clam Ruditapes decussatus.
8(0,0,1,3) Details
16510128 Patel S, Singh V, Kumar A, Gupta YK, Singh MP: Status of antioxidant defense system and expression of toxicant responsive genes in striatum of maneb- and paraquat-induced Parkinson's disease phenotype in mouse: mechanism of neurodegeneration. Brain Res. 2006 Apr 7;1081(1):9-18. Epub 2006 Feb 28.

The involvement of cytochrome P4502E1 and glutathione S-transferases A4-4 enzymes in the detoxification of several pesticides such as atrazine, fenamirol, organophosphorous insecticide parathion, methoxychlor, diethyl dithiocarbamate and paraquat has been known.
7(0,0,1,2) Details
15620088 Sheweita SA: Carcinogen-metabolizing enzymes and insecticides. J Environ Sci Health B. 2004;39(5-6):805-18.

In addition, the activity of glutathione S-transferase (GST), glutathione reductase (GR), and the level of glutathione (GSH) were determined in the liver of male mice after oral administration of sumithion, dursban, chlordane, methoxychlor, heptachlor epoxide, and lindane as single (24h) or as repeated doses for six consecutive days.
6(0,0,1,1) Details
7082334 Lamartiniere CA, Luther MA, Lucier GW, Illsley NP: Altered imprinting of rat liver monoamine oxidase by o, p'-DDT and methoxychlor. Biochem Pharmacol. 1982 Mar 1;31(5):647-51.

However, glutathione S-transferase activities and cytochrome P-450 content were higher in prepubertal animals treated neonatally with o,p'-DDT.
2(0,0,0,2) Details
11162928 Matthews J, Celius T, Halgren R, Zacharewski T: Differential estrogen receptor binding of estrogenic substances: a species comparison. J Steroid Biochem Mol Biol. 2000 Nov 15;74(4):223-34.

Methoxychlor, p,p'-DDT, o,p'-DDE, p,p'-DDE, alpha-endosulfan and dieldrin weakly bound to the ERs from the human, mouse, chicken and green anole.
The study investigated the ability of 34 natural and synthetic chemicals to compete with [3H] 17beta-estradiol (E2) for binding to bacterially expressed glutathione-S-transferase (GST)-estrogen receptors (ER) fusion proteins from five different species.
1(0,0,0,1) Details
11509743 Waters KM, Safe S, Gaido KW: Differential gene expression in response to methoxychlor and estradiol through ERalpha, ERbeta, and AR in reproductive tissues of female mice. Toxicol Sci. 2001 Sep;63(1):47-56.

0(0,0,0,0) Details