Protein Information

Name aldehyde dehydrogenase (protein family or complex)
Synonyms aldehyde dehydrogenase; aldehyde dehydrogenases

Compound Information

Name formaldehyde
CAS formaldehyde

Reference List

PubMed Abstract RScore(About this table)
19896282 Monte WC: Methanol: A chemical Trojan horse as the root of the inscrutable U. Med Hypotheses. 2009 Nov 4.

Variability in sensitivity to exogenous methanol consumption may be accounted for in part by the presence of aldehyde dehydrogenase sufficient to reduce the toxic effect of formaldehyde production in tissue through its conversion to the much less toxic formic acid.
81(1,1,1,1) Details
19184326 Jelski W, Kozlowski M, Laudanski J, Niklinski J, Szmitkowski M: Alcohol dehydrogenase isoenzymes and aldehyde dehydrogenase activity in the sera of patients with esophageal cancer. Clin Exp Med. 2009 Jun;9(2):131-7. Epub 2009 Jan 30.

The activity of class III alcohol dehydrogenase was measured by the photometric method with formaldehyde and class IV with m-nitrobenzaldehyde as a substrate.
3(0,0,0,3) Details
18231859 Jelski W, Chrostek L, Zalewski B, Szmitkowski M: Alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) activity in the sera of patients with gastric cancer. Dig Dis Sci. 2008 Aug;53(8):2101-5. Epub 2008 Jan 30.

3(0,0,0,3) Details
18095160 Jelski W, Zalewski B, Szmitkowski M: Alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) activity in the sera of patients with pancreatic cancer. Dig Dis Sci. 2008 Aug;53(8):2276-80. Epub 2007 Dec 20.

3(0,0,0,3) Details
18224440 Jelski W, Zalewski B, Szmitkowski M: The activity of class I, II, III, and IV alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) in liver cancer. Dig Dis Sci. 2008 Sep;53(9):2550-5. Epub 2008 Jan 26.

2(0,0,0,2) Details
18188528 Jelski W, Zalewski B, Chrostek L, Szmitkowski M: Alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) activity in the sera of patients with colorectal cancer. Clin Exp Med. 2007 Dec;7(4):154-7. Epub 2008 Jan 11.

The activity of class III ADH was measured by the photometric method with formaldehyde and class IV with m-nitrobenzaldehyde as a substrate.
2(0,0,0,2) Details
17675378 Ohhata N, Yoshida N, Egami H, Katsuragi T, Tani Y, Takagi H: An extremely oligotrophic bacterium, Rhodococcus erythropolis N9T-4, isolated from crude oil. J Bacteriol. 2007 Oct;189(19):6824-31. Epub 2007 Aug 3.

The primary structures of these proteins exhibited striking similarities to those of methanol: N,N'-dimethyl-4-nitrosoaniline oxidoreductase and an aldehyde dehydrogenase from Rhodococcus sp.
These results suggest that CO (2) fixation involves methanol (formaldehyde) metabolism in the oligotrophic growth of R. erythropolis N9T-4.
2(0,0,0,2) Details
18484658 Jelski W, Zalewski B, Szmitkowski M: Alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) activity in the sera of patients with liver cancer. J Clin Lab Anal. 2008;22(3):204-9.

The activity of class III ADH was measured by the photometric method with formaldehyde and class IV with m-nitrobenzaldehyde as a substrate.
2(0,0,0,2) Details
17632320 Jelski W, Chrostek L, Szmitkowski M: The activity of class I, II, III, and IV of alcohol dehydrogenase isoenzymes and aldehyde dehydrogenase in pancreatic cancer. Pancreas. 2007 Aug;35(2):142-6.

2(0,0,0,2) Details
18621148 Hu Y, Khan IA, Dasmahapatra AK: Disruption of circulation by ethanol promotes fetal alcohol spectrum disorder (FASD) in medaka (Oryzias latipes) embryogenesis. Comp Biochem Physiol C Toxicol Pharmacol. 2008 Sep;148(3):273-80. Epub 2008 Jun 22.


We further analyzed alcohol dehydrogenase (Adh 5 and adh8) and aldehyde dehydrogenase (Aldh9A and Aldh1A2) enzyme mRNAs in the embryos exposed to 400 mM ethanol for 24 h.
1(0,0,0,1) Details
18850629 Lopez-Sanchez LM, Corrales FJ, Gonzalez R, Ferrin G, Munoz-Castaneda JR, Ranchal I, Hidalgo AB, Briceno J, Lopez-Cillero P, Gomez MA, De La Mata M, Muntane J, Rodriguez-Ariza A: Alteration of S-nitrosothiol homeostasis and targets for protein S-nitrosation in human hepatocytes. Proteomics. 2008 Nov;8(22):4709-20.


Twenty S-nitrosoproteins were identified in CSNO-treated hepatocytes, including mitochondrial aldehyde dehydrogenase, protein disulphide isomerase, Hsp60, GRP75 and Raf kinase inhibitor protein.
1(0,0,0,1) Details