Protein Information

Name mitogen activated protein kinase (protein family or complex)
Synonyms MAPK; mitogen activated protein kinase; mitogen activated protein kinases

Compound Information

Name formaldehyde
CAS formaldehyde

Reference List

PubMed Abstract RScore(About this table)
18033311 Zhou Z, Peng X, Hao S, Fink DJ, Mata M: HSV-mediated transfer of interleukin-10 reduces inflammatory pain through modulation of membrane tumor necrosis factor alpha in spinal cord microglia. Gene Ther. 2008 Feb;15(3):183-90. Epub 2007 Nov 22.


IL-10 reduced the phosphorylation of p38 mitogen-activated protein kinase (MAPK) and decreased the expression of full-length membrane spanning tumor necrosis factor-alpha (mTNFalpha) following lipopolysaccharide stimulation of microglia in vitro.
2(0,0,0,2) Details
19214432 Li YH, Wang YY, Zhong S, Rong ZL, Ren YM, Li ZY, Zhang SP, Chang ZJ, Liu L: Transmembrane helix of novel oncogene with kinase-domain (NOK) influences its oligomerization and limits the activation of RAS/MAPK signaling. Mol Cells. 2009 Jan;27(1):39-45. Epub 2009 Feb 5.

The results further showed that NOK aggregated more closely as lower order oligomers (the dimer- and trimer-sized) than either deletion mutant did since NOK could be cross-linked by both Sulfo-EGS and formaldehyde, whereas either deletion mutant was only sensitive to Sulfo-EGS.
2(0,0,0,2) Details
18849615 Sasaki Y, Ohtani T, Ito Y, Mizuashi M, Nakagawa S, Furukawa T, Horii A, Aiba S: Molecular events in human T cells treated with diesel exhaust particles or formaldehyde that underlie their diminished interferon-gamma and interleukin-10 production. Int Arch Allergy Immunol. 2009;148(3):239-50. Epub 2008 Oct 10.

METHODS: To identify the molecular events by which DEP and FA induce a Th2-skewed immune response, we stimulated T cells from healthy subjects with anti-CD3/anti-CD28 monoclonal antibodies and examined the effect of pretreatment with DEP or FA on mitogen-activated protein kinases (MAPKs) and nuclear factor (NF)-kappaB by Western blotting and colorimetric NF-kappaB assays.
1(0,0,0,1) Details
18329177 Seo YJ, Kwon MS, Choi SS, Han EJ, Jung JS, Choi HW, Park SH, Jang JE, Suh HW: Characterization of the hypothalamic proopiomelanocortin gene and beta-endorphin expression in the hypothalamic arcuate nucleus of mice elicited by inflammatory pain. Neuroscience. 2008 Apr 9;152(4):1054-66. Epub 2007 Jul 17.


PD98059 (mitogen-activated protein kinase (MAPK) pathways inhibitor; 6.6 mug) and KN93 (pCaMK-II inhibitor; 20 mug).
1(0,0,0,1) Details
18706764 Cao JL, Ruan JP, Ling DY, Guan XH, Bao Q, Yuan Y, Zhang LC, Song XJ, Zeng YM: Activation of peripheral ephrinBs/EphBs signaling induces hyperalgesia through a MAPKs-mediated mechanism in mice. Pain. 2008 Oct 31;139(3):617-31. Epub 2008 Aug 15.


EphrinB1-Fc-induced hyperalgesia is accompanied with the NMDA receptor-mediated increase of expression in peripheral and spinal phosphorylated mitogen-activated protein kinases (phospho-MAPKs) including p-p38, pERK and pJNK, and also is prevented or reversed by the inhibition of peripheral and spinal MAPKs.
1(0,0,0,1) Details