Protein Information

Name cyclooxygenase 2
Synonyms COX 2; COX2; PHS2; PGG/HS; Cyclooxygenase 2; Cyclooxygenase 2b; Cycloxygenase 2; PGH synthase 2…

Compound Information

Name formaldehyde
CAS formaldehyde

Reference List

PubMed Abstract RScore(About this table)
19152369 Bawa AS, Khanum F: Anti-inflammatory activity of Rhodiola rosea--"a second-generation adaptogen". Methods Find Exp Clin Pharmacol. 2007 Jul-Aug;29(6):383-8.

The anti-inflammatory activity was determined through carrageenan-induced paw oedema, formaldehyde-induced arthritis and nystatin-induced paw oedema in rat model.
The enzymes include cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2) and Phospholipase A2 (PLA2).
2(0,0,0,2) Details
18292448 Lee IO, Seo Y: The effects of intrathecal cyclooxygenase-1, cyclooxygenase-2, or nonselective inhibitors on pain behavior and spinal Fos-like immunoreactivity. Anesth Analg. 2008 Mar;106(3):972-7

1(0,0,0,1) Details
17922065 Guo CX, Irwin MG, Cheung KM, Chan D: An effective dose of valdecoxib in experimental mouse models of pain. table of contents.


The effects of selective cyclooxygenase-2 (COX-2) inhibitors in biological functions are frequently investigated in animal models.
1(0,0,0,1) Details
18329681 Aguirre-Banuelos P, Escudero-Lourdes C, Sanchez-Pena LC, Del Razo LM, Perez-Urizar J: Inorganic arsenic exposure affects pain behavior and inflammatory response in rat. Toxicol Appl Pharmacol. 2008 Jun 15;229(3):374-85. Epub 2008 Feb 7.


In vitro studies have suggested that iAs can modulate the activity of macrophages producing an over-expression of cyclooxygenase-2 (COX-2) and resulting in an increase in prostaglandin E (2) (PGE (2)) concentrations in endothelial cells.
1(0,0,0,1) Details
17703974 Dudhgaonkar SP, Tandan SK, Kumar D, Arunadevi R, Prakash VR: Synergistic interaction between meloxicam and aminoguanidine in formalin-induced nociception in mice. Appl Immunohistochem Mol Morphol. 2007 Sep;15(3):338-42.


OBJECTIVES: The objective of this study was to examine the nature of interaction between cyclooxygenase-2 inhibitor meloxicam and inducible nitric oxide synthase inhibitor aminoguanidine in formalin-induced nociception in mice and the possible therapeutic advantage.
1(0,0,0,1) Details
17721281 Castiglione F, Degl'Innocenti DR, Taddei A, Garbini F, Buccoliero AM, Raspollini MR, Pepi M, Paglierani M, Asirelli G, Freschi G, Bechi P, Taddei GL: Real-time PCR analysis of RNA extracted from formalin-fixed and paraffin-embeded tissues: effects of the fixation on outcome reliability. Phytother Res. 2009 Aug;23(8):1099-102.


We compared RNA levels with 70 colic mucosa samples using the cyclooxygenase 2 gene as marker.
1(0,0,0,1) Details