Protein Information

Name alcohol dehydrogenase (protein family or complex)
Synonyms ADH; alcohol dehydrogenase; alcohol dehydrogenases

Compound Information

Name formaldehyde
CAS formaldehyde

Reference List

PubMed Abstract RScore(About this table)
19896282 Monte WC: Methanol: A chemical Trojan horse as the root of the inscrutable U. Med Hypotheses. 2009 Nov 4.

The known sites of class I alcohol dehydrogenase (ADH I), the only human enzyme capable of metabolizing methanol to formaldehyde, correspond to the sites of origin for many DOC.
81(1,1,1,1) Details
19184326 Jelski W, Kozlowski M, Laudanski J, Niklinski J, Szmitkowski M: Alcohol dehydrogenase isoenzymes and aldehyde dehydrogenase activity in the sera of patients with esophageal cancer. Clin Exp Med. 2009 Jun;9(2):131-7. Epub 2009 Jan 30.

The activity of class III alcohol dehydrogenase was measured by the photometric method with formaldehyde and class IV with m-nitrobenzaldehyde as a substrate.
37(0,1,1,7) Details
19460944 Thompson CM, Sonawane B, Grafstrom RC: The ontogeny, distribution, and regulation of alcohol dehydrogenase 3: implications for pulmonary physiology. Drug Metab Dispos. 2009 Aug;37(8):1565-71. Epub 2009 May 21.

Class III alcohol dehydrogenase (ADH3), also termed formaldehyde dehydrogenase or S-nitrosoglutathione reductase, plays a critical role in the enzymatic oxidation of formaldehyde and reduction of nitrosothiols that regulate bronchial tone.
31(0,1,1,1) Details
19883652 Guo L, Zeng XY, Wang DY, Li GQ: Methanol metabolism in the Asian corn borer, Ostrinia furnacalis (Guenee) (Lepidoptera: Pyralidae). J Insect Physiol. 2009 Nov 10.

These data indicate that alcohol dehydrogenase, and probably catalase and cytochrome P450 monooxygenase oxidize methanol to formaldehyde, catalase and cytochrome P450 monooxygenase catalyze formaldehyde to formic acid, water and carbon dioxide, and carboxylesterase may have a minor effect.
31(0,1,1,1) Details
18095160 Jelski W, Zalewski B, Szmitkowski M: Alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) activity in the sera of patients with pancreatic cancer. Dig Dis Sci. 2008 Aug;53(8):2276-80. Epub 2007 Dec 20.

8(0,0,0,8) Details
18231859 Jelski W, Chrostek L, Zalewski B, Szmitkowski M: Alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) activity in the sera of patients with gastric cancer. Dig Dis Sci. 2008 Aug;53(8):2101-5. Epub 2008 Jan 30.

5(0,0,0,5) Details
18364675 Jelski W, Grochowska-Skiba B, Szmitkowski M: [Alcohol dehydrogenase and the metabolism of ethanol in the brain] . Postepy Hig Med Dosw. 2007 Apr 24;61:226-30.

2(0,0,0,2) Details
17591795 Kidd SP, Jiang D, Jennings MP, McEwan AG: Glutathione-dependent alcohol dehydrogenase AdhC is required for defense against nitrosative stress in Haemophilus influenzae. Infect Immun. 2007 Sep;75(9):4506-13. Epub 2007 Jun 25.

2(0,0,0,2) Details
18484658 Jelski W, Zalewski B, Szmitkowski M: Alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) activity in the sera of patients with liver cancer. J Clin Lab Anal. 2008;22(3):204-9.

The activity of class III ADH was measured by the photometric method with formaldehyde and class IV with m-nitrobenzaldehyde as a substrate.
2(0,0,0,2) Details
17632320 Jelski W, Chrostek L, Szmitkowski M: The activity of class I, II, III, and IV of alcohol dehydrogenase isoenzymes and aldehyde dehydrogenase in pancreatic cancer. Pancreas. 2007 Aug;35(2):142-6.

2(0,0,0,2) Details
18224440 Jelski W, Zalewski B, Szmitkowski M: The activity of class I, II, III, and IV alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) in liver cancer. Dig Dis Sci. 2008 Sep;53(9):2550-5. Epub 2008 Jan 26.

2(0,0,0,2) Details
17404875 Jelski W, Chrostek L, Laszewicz W, Szmitkowski M: Alcohol dehydrogenase (ADH) isoenzyme activity in the sera of patients with Helicobacter pylori infection. Dig Dis Sci. 2007 Jun;52(6):1513-6. Epub 2007 Apr 3.

The activities of class III and IV ADH isoenzymes were measured by the photometric method with formaldehyde and with m-nitrobenzaldehyde as substrate, respectively.
2(0,0,0,2) Details
18188528 Jelski W, Zalewski B, Chrostek L, Szmitkowski M: Alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) activity in the sera of patients with colorectal cancer. Clin Exp Med. 2007 Dec;7(4):154-7. Epub 2008 Jan 11.

The activity of class III ADH was measured by the photometric method with formaldehyde and class IV with m-nitrobenzaldehyde as a substrate.
2(0,0,0,2) Details
18621148 Hu Y, Khan IA, Dasmahapatra AK: Disruption of circulation by ethanol promotes fetal alcohol spectrum disorder (FASD) in medaka (Oryzias latipes) embryogenesis. Comp Biochem Physiol C Toxicol Pharmacol. 2008 Sep;148(3):273-80. Epub 2008 Jun 22.


We further analyzed alcohol dehydrogenase (Adh 5 and adh8) and aldehyde dehydrogenase (Aldh9A and Aldh1A2) enzyme mRNAs in the embryos exposed to 400 mM ethanol for 24 h.
1(0,0,0,1) Details
19011751 Persson B, Hedlund J, Jornvall H: Medium- and short-chain dehydrogenase/reductase gene and protein families : the MDR superfamily. Cell Mol Life Sci. 2008 Dec;65(24):3879-94.


The MDR superfamily with ~350-residue subunits contains the classical liver alcohol dehydrogenase (ADH), quinone reductase, leukotriene B4 dehydrogenase and many more forms.
1(0,0,0,1) Details
19581469 Skinner K, Cuiffetti L, Hyman M: Metabolism and cometabolism of cyclic ethers by a filamentous fungus, a Graphium sp. Appl Environ Microbiol. 2009 Sep;75(17):5514-22. Epub 2009 Jul 6.

Collectively, these observations suggest that THF and n-alkanes may initially be oxidized by the same monooxygenase and that further transformation of THF-derived metabolites involves the activity of one or more alcohol dehydrogenases.
Mycelia grown on propane or THF exhibited comparable high levels of hemiacetal-oxidizing activity that generated methyl formate from mixtures of formaldehyde and methanol.
1(0,0,0,1) Details