Protein Information

Name semicarbazide sensitive amine oxidase
Synonyms AOC 3; DAO; Diamine oxidase; Histaminase; Amine oxidase; AOC3; AOC3 Human placenta amine oxidase; Copper amine oxidase…

Compound Information

Name formaldehyde
CAS formaldehyde

Reference List

PubMed Abstract RScore(About this table)
17401529 Chen K, Kazachkov M, Yu PH: Effect of aldehydes derived from oxidative deamination and oxidative stress on beta-amyloid aggregation; pathological implications to Alzheimer's disease. J Neural Transm. 2007;114(6):835-9. Epub 2007 Mar 31.

Formaldehyde and methylglyoxal are generated via deamination from methylamine and aminoacetone respectively catalyzed by semicarbazide-sensitive amine oxidase (SSAO).
81(1,1,1,1) Details
17596537 Kazachkov M, Chen K, Babiy S, Yu PH: Evidence for in vivo scavenging by aminoguanidine of formaldehyde produced via semicarbazide-sensitive amine oxidase-mediated deamination. J Pharmacol Exp Ther. 2007 Sep;322(3):1201-7. Epub 2007 Jun 27.
65(0,2,2,5) Details
18845121 Xiao S, Yu PH: A fluorometric high-performance liquid chromatography procedure for simultaneous determination of methylamine and aminoacetone in blood and tissues. Anal Biochem. 2009 Jan 1;384(1):20-6. Epub 2008 Sep 25.

They can be oxidized by semicarbazide-sensitive amine oxidase (SSAO), leading to the production of toxic aldehydes such as formaldehyde and methylglyoxal as well as hydrogen peroxide and ammonia.
33(0,1,1,3) Details
18357780 Dmitrenko NP, Holian A: [Role of interaction of metabolism pathways of formaldehyde and nitric oxide in the mechanism of their toxic effect. 3. Ukr Biokhim Zh. 2007 Sep-Oct;79(5):72-90.

0(0,0,0,0) Details