| 18303411 |
Mehra S, de la Roza G, Tull J, Shrimpton A, Valente A, Zhang S: Detection of FOXO1 (FKHR) gene break-apart by fluorescence in situ hybridization in formalin-fixed, paraffin-embedded alveolar rhabdomyosarcomas and its clinicopathologic correlation. Diagn Mol Pathol. 2008 Mar;17(1):14-20.
Chromosomal translocations of t (2;13)(q35;q14) and t (1;13)(p36;q14), resulting in PAX3-FOXO1 (FKHR) and PAX7-FOXO1 (FKHR) gene fusions, have been found to be specific molecular markers for alveolar rhabdomyosarcomas (ARMS) and can be identified in approximately 80% cases. |
5(0,0,0,5) |
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| 19704258 |
Downs-Kelly E, Shehata BM, Lopez-Terrada D, Weaver J, Patel RM, Hartke M, Tubbs RR, Skacel M, Goldblum JR: The utility of FOXO1 fluorescence in situ hybridization (FISH) in formalin-fixed paraffin-embedded specimens in the diagnosis of alveolar rhabdomyosarcoma. Diagn Mol Pathol. 2009 Sep;18(3):138-43.
Alveolar rhabdomyosarcoma (ARMS) is an aggressive neoplasm with unique t (2;13)(q35;q14) or t (1;13)(p36;q14) chromosomal translocations, resulting in PAX3/FOXO1 and PAX7/FOXO1 fusion genes, in approximately 80% of cases. |
5(0,0,0,5) |
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