Protein Information

Name CD8
Synonyms CD8; p32; MAL; CD8A; CD8a antigen; CD8a molecule; LEU2 T lymphocyte antigen; Leu2…

Compound Information

Name formaldehyde
CAS formaldehyde

Reference List

PubMed Abstract RScore(About this table)
18544843 Zou WY, Guo QL, Cai J, Wang E, Yang HW, Xu DM, Wang YC: [Effect of intrathecal pumping tramadol on the immune function in rats with formalin pain]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2008 May;33(5):404-9.


Phenotypic expressions of cell surface markers of T lymphocyte subsets (CD3+, CD3+ CD4+, CD3+ CD8+, and CD4+/ CD8+) and NK cell (CD161+) in the spleen were analyzed by flow cytometry.
1(0,0,0,1) Details
18669168 Sandikci M, Eren U, Kum S: Effects of formaldehyde and xylene on CD4- and CD8-positive T cells in bronchus-associated lymphoid tissue in rats. Toxicol Ind Health. 2007 Sep;23(8):471-7.
14(0,0,2,4) Details
17716684 van Bockel D, Price DA, Asher TE, Venturi V, Suzuki K, Warton K, Davenport MP, Cooper DA, Douek DC, Kelleher AD: Validation of RNA-based molecular clonotype analysis for virus-specific CD8+ T-cells in formaldehyde-fixed specimens isolated from peripheral blood. J Immunol Methods. 2007 Sep 30;326(1-2):127-38. Epub 2007 Aug 9.
7(0,0,1,2) Details
17712393 Recavarren S, Recavarren R, Recavarren C: [Microscopic colitis: pathogenesis] . Rev Gastroenterol Peru. 2007 Apr-Jun;27(2):155-60.

Biopsies were fixed in neutral formaldehyde, processed through the paraffin inclusion method, and stained with hematoxiline-eosine and Masson trichromic to distinguish collagenous tissue.
Based on this, the authors of this study hypothesize that lymphocytic infiltration of the lamina propria could be related to cytotoxic lymphocytes CD8 as causative agents of colon tissue damage.
1(0,0,0,1) Details
18776164 Randall KJ, Pearse G: A dual-label technique for the immunohistochemical demonstration of T-lymphocyte subsets in formalin-fixed, paraffin-embedded rat lymphoid tissue. Toxicol Pathol. 2008;36(6):795-804. Epub 2008 Sep 5.


Taking the assumption that the majority of mature T-cells are either CD4+ or CD8+, we have combined our methods for CD3 and CD8 in a novel dual-labeling IHC method to simultaneously demonstrate CD3, CD8, and, by implication, CD4 in rat spleen, thymus, lymph node, and Peyer's patch.
1(0,0,0,1) Details