Protein Information

Name RGL2
Synonyms HKE1.5; KE1.5; RAB2L; RAS associated protein RAB2L; RGL 2; RGL2; Ral guanine nucleotide dissociation stimulator like 2; RalGDS like factor…

Compound Information

Name gibberellic acid
CAS (1α,2β,4aα,4bβ,10β)-2,4a,7-trihydroxy-1-methyl-8-methylenegibb-3-ene-1,10-dicarboxylic acid 1,4a-lactone

Reference List

PubMed Abstract RScore(About this table)
18941053 Piskurewicz U, Jikumaru Y, Kinoshita N, Nambara E, Kamiya Y, Lopez-Molina L: The gibberellic acid signaling repressor RGL2 inhibits Arabidopsis seed germination by stimulating abscisic acid synthesis and ABI5 activity. Plant Cell. 2008 Oct;20(10):2729-45. Epub 2008 Oct 21.
34(0,1,1,4) Details
16167898 Hussain A, Cao D, Cheng H, Wen Z, Peng J: Identification of the conserved serine/threonine residues important for gibberellin-sensitivity of Arabidopsis RGL2 protein. Plant J. 2005 Oct;44(1):88-99.

5(0,0,0,5) Details
17704233 Gan Y, Yu H, Peng J, Broun P: Genetic and molecular regulation by DELLA proteins of trichome development in Arabidopsis. Plant Physiol. 2007 Nov;145(3):1031-42. Epub 2007 Aug 17.


In this study, we have probed the relative roles played by RGA, GAI, and two homologs, RGA-LIKE1 (RGL1) and RGL2, in these processes and investigated molecular mechanisms through which they influence epidermal differentiation.
2(0,0,0,2) Details
16916886 Yuan K, Wysocka-Diller J: Phytohormone signalling pathways interact with sugars during seed germination and seedling development. J Exp Bot. 2006;57(12):3359-67. Epub 2006 Aug 17.


This study demonstrates that the ABA Insensitive 3 (ABI3) gene in the ABA signalling pathway and the RGA-like 2 (RGL2) and SPINDLY (SPY) genes in the GA signalling pathways all play important roles in the glucose-induced delay of seed germination.
2(0,0,0,2) Details
16339853 Ward JM, Smith AM, Shah PK, Galanti SE, Yi H, Demianski AJ, van der Graaff E, Keller B, Neff MM: A new role for the Arabidopsis AP2 transcription factor, LEAFY PETIOLE, in gibberellin-induced germination is revealed by the misexpression of a homologous gene, SOB2/DRN-LIKE. Plant Cell. 2006 Jan;18(1):29-39. Epub 2005 Dec 9.

These results suggest LEP is a positive regulator of GA-induced germination acting independently of RGL2.
Gibberellic acid (GA) promotes germination, stem/hypocotyl elongation, and leaf expansion during seedling development.
2(0,0,0,2) Details
18363782 Kim SG, Lee AK, Yoon HK, Park CM: A membrane-bound NAC transcription factor NTL8 regulates gibberellic acid-mediated salt signaling in Arabidopsis seed germination. Plant J. 2008 Jul;55(1):77-88.

Interestingly, NTL8 is significantly induced during cold imbibition, but the induction declines quickly in germinating seeds, like RGL2.
1(0,0,0,1) Details
19704528 Kim SG, Park CM: Gibberellic acid-mediated salt signaling in seed germination. Plant Signal Behav. 2008 Oct;3(10):877-9.

We recently demonstrated that a membrane-bound NAC transcription factor, NTL8, mediates salt signaling, primarily through a RGL2-independent GA pathway, in regulating seed germination.
1(0,0,0,1) Details
16034591 Cao D, Hussain A, Cheng H, Peng J: Loss of function of four DELLA genes leads to light- and gibberellin-independent seed germination in Arabidopsis. Planta. 2005 Dec;223(1):105-13. Epub 2005 Jul 21.


In this report, using ga1-3 mutation as the genetic background, we confirm that RGL2, one member of the DELLA family, encodes the predominant repressor of seed germination in Arabidopsis and show that the other DELLA genes GAI,RGA and RGL1 enhance the function of RGL2.
1(0,0,0,1) Details