| Name | mitogen activated protein kinase (protein family or complex) |
|---|---|
| Synonyms | MAPK; mitogen activated protein kinase; mitogen activated protein kinases |
| Name | benzalkonium chloride |
|---|---|
| CAS | quaternary ammonium compounds, alkylbenzyldimethyl, chlorides |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12164931 | Brand P, Plochmann S, Valk E, Zahn S, Saloga J, Knop J, Becker D: Activation and translocation of p38 mitogen-activated protein kinase after stimulation of monocytes with contact sensitizers. J Invest Dermatol. 2002 Jul;119(1):99-106. In this study, the role of the p38 mitogen-activated protein kinase for the activation of human monocytes after exposure to four structurally unrelated contact sensitizers was analyzed in comparison with the irritant benzalkonium chloride and an inductor of oxidative stress (H2O2) using immunofluorescence, Western blotting, and enzyme-linked immunosorbent assay techniques. |
35(0,1,1,5) | Details |
| 11238627 | Arrighi JF, Rebsamen M, Rousset F, Kindler V, Hauser C: A critical role for p38 mitogen-activated protein kinase in the maturation of human blood-derived dendritic cells induced by lipopolysaccharide, TNF-alpha, and contact sensitizers. J Immunol. 2001 Mar 15;166(6):3837-45. The irritants SDS and benzalkonium chloride that do not induce DC maturation did not trigger p38 MAPK phosphorylation. |
6(0,0,0,6) | Details |
| 12603851 | Aiba S, Manome H, Nakagawa S, Mollah ZU, Mizuashi M, Ohtani T, Yoshino Y, Tagami H: p38 Mitogen-activated protein kinase and extracellular signal-regulated kinases play distinct roles in the activation of dendritic cells by two representative haptens, NiCl2 and 2,4-dinitrochlorobenzene. J Invest Dermatol. 2003 Mar;120(3):390-9. Although recently, the crucial role of p38 mitogen-activated protein kinase has been reported in the activation of dendritic cells by haptens, the signal transduction elements involved in each phenotypic and functional changes that occur in the activation of dendritic cells by haptens remain unknown. In contrast, primary irritants, e.g., benzalkonium chloride, or did not activate these signal transduction pathways. |
2(0,0,0,2) | Details |
| 19490838 | Suzuki M, Hirota M, Hagino S, Itagaki H, Aiba S: Evaluation of changes of cell-surface thiols as a new biomarker for in vitro sensitization test. Toxicol In Vitro. 2009 Jun;23(4):687-96. Epub 2009 Feb 11. First, we found that a decrease of cell-surface thiols on hapten-treated THP-1 cells was induced in parallel with phosphorylation of p38 MAPK. Changes of cell-surface thiols on THP-1 cells were detected after 2h treatment with most allergens (e.g., DNCB, NiSO (4)), as well as some non-allergens (e.g., Tween80, benzalkonium chloride), though other non-allergens (e.g., SDS, had no effect. |
1(0,0,0,1) | Details |