| Name | G proteins |
|---|---|
| Synonyms | G gamma I; Guanine nucleotide binding protein 2; G protein; GNG 2; GNG2; GNGT 2; GNGT2; Guanine nucleotide binding protein gamma 2… |
| Name | benzalkonium chloride |
|---|---|
| CAS | quaternary ammonium compounds, alkylbenzyldimethyl, chlorides |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 8689388 | Estevez MD, Vieytes MR, Botana LM: Mitoxantrone induces nonimmunological release from rat mast cells. Inflamm Res. 1996 Mar;45(3):113-7. release was also unaffected by substances acting on G-proteins, namely pertussis toxin (200 ng/mL), cholera toxin (300 mg/mL) and benzalkonium chloride (10 micrograms/ mL). |
6(0,0,1,1) | Details |
| 17320058 | Gotow T, Nishi T: Involvement of a Go-type G-protein coupled to guanylate cyclase in the phototransduction cascade of molluscan simple photoreceptors. Brain Res. 2007 May 4;1144:42-51. Epub 2007 Jan 26. Furthermore, benzalkonium chloride (C (16) BAC), a selective activator of Go, dose-dependently generated an outward current similar to that induced by mastoparan. |
6(0,0,0,6) | Details |
| 7540143 | Mousli M, Trifilieff A, Pelton JT, Gies JP, Landry Y: Structural requirements for neuropeptide Y in mast cell and G protein activation. Eur J Pharmacol. 1995 Mar 15;289(1):125-33. The releasing effects of neuropeptide Y related peptides were greatly inhibited by pretreatment of rat mast cells with pertussis toxin or benzalkonium chloride. |
3(0,0,0,3) | Details |
| 2117607 | Higashijima T, Burnier J, Ross EM: Regulation of Gi and Go by mastoparan, related amphiphilic peptides, and hydrophobic amines. J Biol Chem. 1990 Aug 25;265(24):14176-86. Mastoparan (MP), a cationic, amphiphilic tetradecapeptide, stimulates nucleotide exchange by GTP-binding regulatory proteins (G proteins) in a manner similar to that of G protein-coupled receptors. 1) MP stimulated exchange by isolated G protein alpha subunits and alpha beta gamma trimers. Several natural amphiphilic peptides also displayed modest stimulatory activity. 6) Benzalkonium chloride competitively antagonized the stimulation of Gi by MP but potently stimulated nucleotide exchange on Go. |
3(0,0,0,3) | Details |
| 10431764 | Daeffler L, Nadra K, Eichwald V, Ohresser S, Landry Y: Effect of NMDA receptor ligands on mast cell release, a reappraisal. Naunyn Schmiedebergs Arch Pharmacol. 1999 Jun;359(6):512-8. Both - and arcaine-induced effects were independent upon extracellular and were largely inhibited by treatment of mast cells with pertussis toxin or benzalkonium chloride. Natural polyamines have been proposed to induce release from mast cells through a direct interaction with G proteins. |
2(0,0,0,2) | Details |
| 7840642 | Khurana ML, Pandey KN: Catalytic activation of guanylate cyclase/atrial natriuretic factor receptor by combined effects of ANF and GTP gamma S in plasma membranes of Leydig tumor cells: involvement of G-proteins. Arch Biochem Biophys. 1995 Jan 10;316(1):392-8. A significant stimulation of GC activity was observed in the presence of mastoparan, AlF4-, and benzalkonium chloride. |
2(0,0,0,2) | Details |
| 1695472 | Bueb JL, Mousli M, Landry Y, Bronner C: A pertussis toxin-sensitive G protein is required to induce release from rat peritoneal mast cells by bradykinin. Agents Actions. 1990 Apr;30(1-2):98-101. release was dose-dependently inhibited by pertussis toxin (1-100 ng/ml) and by benzalkonium chloride (0.1-3 micrograms/ml). |
2(0,0,0,2) | Details |
| 9448721 | Zorko M, Pooga M, Saar K, Rezaei K, Langel U: Differential regulation of GTPase activity by mastoparan and galparan. Arch Biochem Biophys. 1998 Jan 15;349(2):321-8. It is suggested that the reversal of GTPase activation by mastoparan to inhibition by galparan is due to different loci of action of these two peptides on G proteins. Mastoparan reversed the effect of galparan in a fully competitive manner while benzalkonium chloride did not prevent the inhibition of GTPase activity by galparan. |
1(0,0,0,1) | Details |
| 1372167 | Bueb JL, Da Silva A, Mousli M, Landry Y: Natural polyamines stimulate G-proteins. . Biochem J. 1992 Mar 1;282 ( Pt 2):545-50. The activation of rat mast cells by polyamines was inhibited by benzalkonium chloride or by a 2 h pretreatment of the cells with pertussis toxin. |
1(0,0,0,1) | Details |
| 9137989 | Estevez MD, Vieytes MR, Louzao MC, Alfonso A, Vilarino N, Botana LM: The antineoplastic drug vinorelbine activates non-immunological release from rat mast cells. Inflamm Res. 1997 Apr;46(4):119-24. TREATMENT: Vinorelbine (5-100 micrograms/mL), cholera toxin (200 ng/mL), pertussis toxin (100 ng/mL), benzalkonium chloride (10 micrograms/mL), compound 48/80 (1 microgram/mL), okadaic acid (1 microM), 12-- (50 ng/ml), perphenazine (1 microgram/ml), (10 mM), IBMX (1 mM), rolipram (15 microM). |
0(0,0,0,0) | Details |
| 10844094 | Seebeck J, Krebs D, Ziegler A: Influence of salmeterol and benzalkonium chloride on G-protein-mediated exocytotic responses of rat peritoneal mast cells. Eur J Pharmacol. 2000 May 26;397(1):19-24. Low concentrations of benzalkonium chloride have been shown to inhibit exocytotic responses in rat peritoneal mast cells by selectively interacting with heterotrimeric G-proteins of the G (i)-type. |
114(1,2,2,4) | Details |
| 9565765 | Chahdi A, Daeffler L, Gies JP, Landry Y: Drugs interacting with G protein alpha subunits: selectivity and perspectives. Fundam Clin Pharmacol. 1998;12(2):121-32. Benzalkonium chloride and methoctramine have agonist or antagonist properties, depending on G protein subtypes. |
86(1,1,1,6) | Details |
| 9606019 | Chahdi A, Daeffler L, Bueb JL, Gies JP, Landry Y: The M2 muscarinic receptor antagonist methoctramine activates mast cells via pertussis toxin-sensitive G proteins. Naunyn Schmiedebergs Arch Pharmacol. 1998 Apr;357(4):357-62. Benzalkonium chloride, a selective inhibitor of secretion induced by basic secretagogues, inhibited the secretory response to methoctramine. [p-Glu5, D-Trp7,9,l0]-SPs5-11 (GPAnt-2), a well-characterized antagonist of G proteins, blocked the methoctramine-induced release when the antagonist was allowed to reach its intracellular target by streptolysin O-permeabilization. |
84(1,1,1,4) | Details |
| 7536161 | Emadi-Khiav B, Mousli M, Bronner C, Landry Y: Human and rat cutaneous mast cells: involvement of a G protein in the response to peptidergic stimuli. Eur J Pharmacol. 1995 Jan 5;272(1):97-102. The hydrolysis of residues by neuraminidase and the inhibition of G proteins by benzalkonium chloride or pertussis toxin significantly inhibited the secretory response of cutaneous mast cells to neuropeptide Y-(18-36) and mastoparan. |
84(1,1,1,4) | Details |
| 7627138 | Vidal M, Lefevre F, Rouot B, Sainte-Marie J, Philippot J: A GTP-binding protein modulates a Ca2+ pump present in reticulocyte endocytic vesicles. Biochem Mol Biol Int. 1995 Apr;35(4):889-98. Moreover, mastoparan and benzalkonium chloride, both activators of heterotrimeric G proteins, were found to decrease 45Ca2+ uptake by endocytic vesicles. |
82(1,1,1,2) | Details |
| 10771034 | Mori K, Maru C, Takasuna K, Furuhama K: Mechanism of release induced by levofloxacin, a fluoroquinolone antibacterial agent. Eur J Pharmacol. 2000 Apr 7;394(1):51-5. Unlike that with the ionophore A23187, secretion due to levofloxacin or compound 48/80 was prevented by pretreatment with either pertussis toxin or benzalkonium chloride, a selective inhibitor of G proteins of G (i) subtypes. |
82(1,1,1,2) | Details |
| 11495692 | Yoshida M, Yoshida H, Kitaichi K, Hiramatsu K, Kimura T, Ito Y, Kume H, Yamaki K, Suzuki R, Shibata E, Hasegawa T, Takagi K: Adrenomedullin and proadrenomedullin N-terminal 20 peptide induce release from rat peritoneal mast cell. Regul Pept. 2001 Sep 15;101(1-3):163-8. release, induced by ADM, was significantly and dose-dependently inhibited by the addition of ADM-(22-52) (10 (-5) M), Ca (2+) (0.5 to 2.0 mM), and benzalkonium chloride (3 to 7 microM), a selective inhibitor of Gi type G proteins. |
81(1,1,1,1) | Details |
| 11129100 | Odagaki Y, Nishi N, Koyama T: Functional coupling of GABA (B) receptors with G proteins that are sensitive to N-ethylmaleimide treatment, suramin, and benzalkonium chloride in rat cerebral cortical membranes. J Neural Transm. 2000;107(10):1101-16. These results indicate that GABA (B) receptors in rat cerebral cortex couple to NEM-sensitive G proteins, in particular Gi2, which are sensitive to suramin and benzalkonium chloride. |
38(0,1,2,3) | Details |
| 7686903 | Vitale N, Mukai H, Rouot B, Thierse D, Aunis D, Bader MF: Exocytosis in chromaffin cells. J Biol Chem. 1993 Jul 15;268(20):14715-23. Consistent with this finding, two other known activators of heterotrimeric G proteins, aluminum and benzalkonium chloride, inhibited -evoked catecholamine secretion in streptolysin O-permeabilized chromaffin cells. |
35(0,1,1,5) | Details |
| 1701214 | Bueb JL, Mousli M, Bronner C, Rouot B, Landry Y: Activation of Gi-like proteins, a receptor-independent effect of kinins in mast cells. Mol Pharmacol. 1990 Dec;38(6):816-22. The inhibitory effect of benzalkonium chloride showed that the G proteins involved belong to the Gi type. |
34(0,1,1,4) | Details |
| 8027189 | Haas A, Conradt B, Wickner W: G-protein ligands inhibit in vitro reactions of vacuole inheritance. J Cell Biol. 1994 Jul;126(1):87-97. Inhibition by nonhydrolyzable derivatives, mastoparans, and benzalkonium chloride suggest that GTP-hydrolyzing G proteins may play a key role in the in vitro fusion events. |
32(0,1,1,2) | Details |
| 1373170 | Mousli M, Hugli TE, Landry Y, Bronner C: A mechanism of action for anaphylatoxin C3a stimulation of mast cells. . J Immunol. 1992 Apr 15;148(8):2456-61. was released in a nonlytic manner and the mast cell stimulation by both natural and synthetic factors was sensitive to pertussis toxin, neuraminidase, benzalkonium chloride, and to an excess of The C3a anaphylatoxin also directly stimulates purified G proteins (i.e., GTPase activity) in a dose-dependent manner. |
2(0,0,0,2) | Details |
| 7523149 | Grundemar L, Krstenansky JL, Hakanson R: Neuropeptide Y and truncated neuropeptide Y analogs evoke release from rat peritoneal mast cells. Eur J Pharmacol. 1994 Jun 2;258(1-2):163-6. In addition, we examined whether the release evoked by neuropeptide Y (and by compound 48/80) is sensitive to the G protein inhibitors pertussis toxin and benzalkonium chloride. |
32(0,1,1,2) | Details |
| 7526655 | Mousli M, Landry Y: Role of positive charges of neuropeptide Y fragments in mast cell activation. Agents Actions. 1994 Jun;41 Spec No:C41-2. The secretion induced by NPY fragments was inhibited by the treatment of mast cells with benzalkonium chloride and pertussis toxin indicating the involvement of G proteins. |
31(0,1,1,1) | Details |
| 8471631 | Fischer T, Bronner C, Landry Y, Mousli M: The mechanism of inhibition of alkylamines on the mast-cell peptidergic pathway. Biochim Biophys Acta. 1993 Apr 16;1176(3):305-12. release induced by GTP gamma S and by mastoparan (a venom peptide activating G proteins) was inhibited by pretreating mast cells with 0.1 to 3 micrograms/ml of a mixture of benzalkonium chloride containing in majority a twelve-carbon-atom aliphatic chain (BAC (C approximately 12)). |
31(0,1,1,1) | Details |
| 9716372 | Seebeck J, Kruse ML, Schmidt-Choudhury A, Schmidtmayer J, Schmidt WE: Pituitary adenylate cyclase activating polypeptide induces multiple signaling pathways in rat peritoneal mast cells. Eur J Pharmacol. 1998 Jul 10;352(2-3):343-50. PACAP-induced degranulation of rat peritoneal mast cells was abolished by pertussis toxin and by benzalkonium chloride (IC50: 9.1 microg/ml) indicating the involvement of heterotrimeric G-proteins of the Gi-type. |
7(0,0,1,2) | Details |