| 19591488 |
Manetti F, Cona A, Angeli L, Mugnaini C, Raffi F, Capone C, Dreassi E, Zizzari AT, Tisi A, Federico R, Botta M: Synthesis and biological evaluation of guanidino compounds endowed with subnanomolar affinity as competitive inhibitors of maize polyamine oxidase. J Med Chem. 2009 Aug 13;52(15):4774-85.
Several compounds showed an affinity in the nanomolar range, while a cyclopropylmethyl derivative of iminoctadine was found to be the most potent inhibitor of maize polyamine oxidase reported so far (Ki = 0.08 nM). |
83(1,1,1,3) |
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