| Name | Substance P |
|---|---|
| Synonyms | Hs.2563; PPT; NK2; NKA; NKNA; Neurokinin 1; Neurokinin 2; Neurokinin A… |
| Name | benzalkonium chloride |
|---|---|
| CAS | quaternary ammonium compounds, alkylbenzyldimethyl, chlorides |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 2417614 | Piotrowski W, Foreman JC: Some effects of calcitonin gene-related peptide in human skin and on release. Br J Dermatol. 1986 Jan;114(1):37-46. The substance P analogue, [D-Pro4, D-Trp7,9,10] SP4-11 10 microM, and benzalkonium chloride 10 microM inhibited release from rat mast cells stimulated by either CGRP or substance P. |
82(1,1,1,2) | Details |
| 2444699 | Repke H, Piotrowski W, Bienert M, Foreman JC: release induced by Arg-Pro--Pro (CH2) 11CH3 from rat peritoneal mast cells. J Pharmacol Exp Ther. 1987 Oct;243(1):317-21. Unlike dodecylamine itself, SP1-4C12 induced noncytolytic release which was inhibited by benzalkonium chloride and by the substance P antagonist [D-Pro4,D-Trp7,9,10] SP4-11. |
35(0,1,1,5) | Details |
| 2412242 | Jannasch R: [Capillary isotachophoresis--a new method in drug analysis. 2. Pharmazie. 1985 Jun;40(6):398-403. They served the control of purification methods for substance P as well as the determination of the contents in preparations for this peptide including simultaneously in case of need the preservative benzalkonium chloride with sufficient reproducibility (rel. |
14(0,0,2,4) | Details |
| 2431572 | Wallengren J, Moller H: The effect of on some experimental inflammations in human skin. . Acta Derm Venereol. 1986;66(5):375-80. In experiments on human skin inflammation was induced by injection of substance P (SP) or intradermally, UV irradiation, non-immunologic contact urticaria, tuberculin reaction, contact allergens and benzalkonium chloride with or without pretreatment. |
7(0,0,1,2) | Details |
| 6174350 | Kurose M, Saeki K: release induced by neurotensin from rat peritoneal mast cells. . Eur J Pharmacol. 1981 Dec 3;76(2-3):129-36. The effect of neurotensin was markedly different from that of substance P, bradykinin and compound 48/80 with respect to both the dose-response curve and the sensitivity to benzalkonium chloride. |
6(0,0,1,1) | Details |
| 11239931 | Lau AH, Chow SS, Ng YS: Immunologically induced release from rat peritoneal mast cells is enhanced by low levels of substance P. Eur J Pharmacol. 2001 Mar 2;414(2-3):295-303. While the potentiating effect of substance P was not suppressed by any of the non-peptide tachykinin receptor antagonists CP99994 ((2S,3S)-3-(2-methoxybenzylamino)-2-phenylpiperidine), SR48968 ((S)-N-methyl-N-(4-acetylamino-4-phenylpiperidino)-2-(3,4-dichlorophenyl) butyl-benzamide) and SR142801 ((S)-(N)-(1-[3-(1-benzoyl-3 (3,4-dichlorophenyl) piperidine-3-yl) propyl]-4-p henylpiperidin-4-yl)-N-methyl-acetamide), it was mimicked by compound 48/80 and suppressed by benzalkonium chloride. |
4(0,0,0,4) | Details |
| 2419771 | Piotrowski W, Foreman JC: On the actions of substance P, somatostatin, and vasoactive intestinal polypeptide on rat peritoneal mast cells and in human skin. Naunyn Schmiedebergs Arch Pharmacol. 1985 Dec;331(4):364-8. The release of induced by these neuropeptides was inhibited by preincubation of the cells with the SP analogue [D-Pro4,D-Trp7,9,10]-SP4-11 (SP-A) (10 microM), and also by benzalkonium chloride (10 microM). |
2(0,0,0,2) | Details |
| 2440265 | Piotrowski W, Mead M, Foreman JC: Action of the SP2-11 and SP3-11 fragments of substance P on rat peritoneal mast cells. Agents Actions. 1987 Apr;20(3-4):178-80. Benzalkonium chloride was found to be a competitive antagonist of SP and SP3-11: the dissociation constants for the benzalkonium chloride-receptor interaction being about the same when either SP1-11 or SP3-11 was used as the agonist. |
2(0,0,0,2) | Details |
| 6195330 | Fox DA, Epstein ML, Bass P: Surfactants selectively ablate enteric neurons of the rat jejunum. . J Pharmacol Exp Ther. 1983 Nov;227(2):538-44. Various concentrations of the cationic surfactants benzalkonium chloride (BAC) and benzethonium the anionic surfactants ricinoleate, dioctyl sulfosuccinate and and the nonionic surfactant Triton X-100 were applied to the serosal surface of the rat jejunum every 5 min for 0.5 hr and then rinsed off with saline. BAC treatment markedly reduced the immunoreactivity of somatostatin, substance P, met-enkephalin and vasoactive intestinal peptide in the myenteric plexus. |
1(0,0,0,1) | Details |
| 1701214 | Bueb JL, Mousli M, Bronner C, Rouot B, Landry Y: Activation of Gi-like proteins, a receptor-independent effect of kinins in mast cells. Mol Pharmacol. 1990 Dec;38(6):816-22. The data support the proposal that bradykinin and analogues act like mastoparan, substance P, and compound 48/80, interacting first with residues of the cell surface and then with Gi-like proteins, inducing phospholipase C activation and intracellular mobilization. The inhibitory effect of benzalkonium chloride showed that the G proteins involved belong to the Gi type. |
1(0,0,0,1) | Details |
| 2434341 | Fox DA, Herman JR, Bass P: Differentiation between myenteric plexus and longitudinal muscle of the rat jejunum as the site of action of putative enteric neurotransmitters. Eur J Pharmacol. 1986 Nov 12;131(1):39-47. The myenteric plexus of a segment of rat jejunum was destroyed by serosal application of benzalkonium chloride (BAC). Fifteen days after BAC treatment, both the BAC-treated and an orad control jejunal segment were removed and the mechanical responses of the longitudinal muscle produced by the following substances were examined: substance P, cholecystokinin octapeptide (CCK-8), vasoactive intestinal peptide (VIP), bombesin, [Leu5] enkephalin and somatostatin. |
1(0,0,0,1) | Details |
| 7686903 | Vitale N, Mukai H, Rouot B, Thierse D, Aunis D, Bader MF: Exocytosis in chromaffin cells. J Biol Chem. 1993 Jul 15;268(20):14715-23. The substance P-related peptide, GPAnt-2, known to antagonize the effects of mastoparan on G (o), blocked both the inhibitory effect of mastoparan on secretion and the mastoparan-stimulated GTPase activity in chromaffin granule membranes. Consistent with this finding, two other known activators of heterotrimeric G proteins, aluminum and benzalkonium chloride, inhibited -evoked catecholamine secretion in streptolysin O-permeabilized chromaffin cells. |
1(0,0,0,1) | Details |
| 8617879 | Li Y, Owyang C: Peptone stimulates CCK-releasing peptide secretion by activating intestinal submucosal cholinergic neurons. J Clin Invest. 1996 Mar 15;97(6):1463-70. Mucosal application of lidocaine but not serosal application of benzalkonium chloride which ablates the myenteric neurons in the donor rats also abolished the stimulatory action of the intestinal washings. Furthermore, treatment of the donor rats with a 5HT3 antagonist and a substance P antagonist also prevented the secretion of CCK-RP. |
2(0,0,0,2) | Details |
| 1709039 | Wallengren J: Substance P antagonist inhibits immediate and delayed type cutaneous hypersensitivity reactions. Br J Dermatol. 1991 Apr;124(4):324-8. Spantide, a competitive inhibitor of SP, was injected intracutaneously into the volar aspect of the forearm prior to the following challenges: benzalkonium chloride (irritant delayed reaction), tuberculin (immunological delayed reaction), UVB irradiation, (non-immunological contact urticaria), different food allergens and latex (in patients with immunological contact urticaria). |
2(0,0,0,2) | Details |
| 9274467 | Higham A, Vaillant C, Yegen B, Thompson DG, Dockray GJ: Relation between cholecystokinin and antral innervation in the control of gastric emptying in the rat. Gut. 1997 Jul;41(1):24-32. Benzalkonium chloride (BAC) causes selective lesions in gut myenteric neurons after serosal application. RESULTS: In BAC treated rats radioimmunoassay of tissue extracts revealed a dose related specific loss of gastrin releasing peptide, substance P, and vasoactive intestinal polypeptide immunoreactivities from the treated region, and immunohistochemistry revealed loss of the neuronal marker PGP 9.5 and the afferent neuropeptide calcitonin gene related peptide (CGRP). |
1(0,0,0,1) | Details |
| 15586800 | Riechelmann H, Deutschle T, Stuhlmiller A, Gronau S, Burner H: Nasal toxicity of benzalkonium chloride. . Am J Rhinol. 2004 Sep-Oct;18(5):291-9. Concentrations for interleukin (IL)-6 in the placebo period were 41.5 pg/mL (0.9-91.7 pg/mL) and in the BAC period were 17.6 pg/mL (3.2-65.9 pg/mL; p = 0.46), and concentrations for substance P were 119 pg/mL (58-293 pg/mL) and 131 pg/mL (80-330 pg/mL; p = 0.31), respectively. |
1(0,0,0,1) | Details |
| 1695472 | Bueb JL, Mousli M, Landry Y, Bronner C: A pertussis toxin-sensitive G protein is required to induce release from rat peritoneal mast cells by bradykinin. Agents Actions. 1990 Apr;30(1-2):98-101. release was dose-dependently inhibited by pertussis toxin (1-100 ng/ml) and by benzalkonium chloride (0.1-3 micrograms/ml). The parallel response of rat peritoneal mast cells to kinins and to substance P suggest that these peptides have the same mechanisms of action i.e. activation of a pertussis toxin-sensitive G protein and of phospholipase C defining a peptidergic triggering pathway of mast cells. |
1(0,0,0,1) | Details |
| 92563 | Read GW, Kiefer EF: Benzalkonium chloride: selective inhibitor of release induced by compound 48/80 and other polyamines. J Pharmacol Exp Ther. 1979 Dec;211(3):711-5. |
0(0,0,0,0) | Details |
| 9869608 | Yazdani A, Takahashi T, Bagnol D, Watson SJ, Owyang C: Functional significance of a newly discovered neuropeptide, orphanin FQ, in rat gastrointestinal motility. Gastroenterology. 1999 Jan;116(1):108-17. Tetrodotoxin, veratridine, and long-term serosal application of benzalkonium chloride completely abolished OFQ-induced colonic contractions without affecting myogenic contractions in response to carbachol. |
0(0,0,0,0) | Details |