| Name | IgE |
|---|---|
| Synonyms | IGHE; Ig epsilon chain C region; IgE; immunoglobulin heavy constant epsilon; Ig epsilon chain C regions; IgEs; immunoglobulin heavy constant epsilons |
| Name | benzalkonium chloride |
|---|---|
| CAS | quaternary ammonium compounds, alkylbenzyldimethyl, chlorides |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 7907416 | Baudouin C, Garcher C, Haouat N, Bron A, Gastaud P: Expression of inflammatory membrane markers by conjunctival cells in chronically treated patients with glaucoma. Ophthalmology. 1994 Mar;101(3):454-60. Of these, 48 had received prolonged topical treatments, all containing benzalkonium chloride as a preservative. In all patients, immunocytochemistry was performed in impression cytology specimens, using two monoclonal antibodies against HLA-DR antigens and receptor to IgE CD23. |
2(0,0,0,2) | Details |
| 18715840 | Swiercz R, Halatek T, Wasowicz W, Kur B, Grzelinska Z, Majcherek W: Pulmonary irritation after inhalation exposure to benzalkonium chloride in rats. Int J Occup Med Environ Health. 2008;21(2):157-63. A significantly higher BALF concentration of IL-6 and IgE was noted in animals exposed to single and repeated doses. |
2(0,0,0,2) | Details |
| 12843888 | Blondin C, Cholley B, Haeffner-Cavaillon N, Goldschmidt P: [In vitro effects of antiallergic eyedrops on complement activation induced by particulate matter]. J Fr Ophtalmol. 2003 Apr;26(4):328-36. A solution of 0.01% benzalkonium chloride (BAC), the most widely used preservative in topical eyedrops, was also tested. BACKGROUND: Recent decades have been marked by an increasing number of patients suffering from ocular allergic-like symptoms without being associated with an increase in IgE levels. |
2(0,0,0,2) | Details |
| 2419771 | Piotrowski W, Foreman JC: On the actions of substance P, somatostatin, and vasoactive intestinal polypeptide on rat peritoneal mast cells and in human skin. Naunyn Schmiedebergs Arch Pharmacol. 1985 Dec;331(4):364-8. The release of induced by these neuropeptides was inhibited by preincubation of the cells with the SP analogue [D-Pro4,D-Trp7,9,10]-SP4-11 (SP-A) (10 microM), and also by benzalkonium chloride (10 microM). In addition, SP-A inhibited release induced by compound 48/80, whilst that induced by goat anti-(rat-IgE) was unaffected. |
1(0,0,0,1) | Details |
| 12464050 | Wallengren J: Cutaneous field stimulation of sensory nerve fibers reduces itch without affecting contact dermatitis. Allergy. 2002 Dec;57(12):1195-9. On the fifth day, patients were provoked by epicutaneous application of (allergic contact dermatitis) and benzalkonium chloride (irritant contact dermatitis), and by intradermal tuberculin (delayed immunologic reaction). Twelve other patients with IgE-mediated allergy were treated by CFS on the lower arm for 1 h and were then pricked with and allergen extracts (wheal volume was measured) and were tested using (nonimmunologic contact urticaria; closed test). |
1(0,0,0,1) | Details |
| 19697451 | Hong J, Bielory L: Allergy to ophthalmic preservatives. Curr Opin Allergy Clin Immunol. 2009 Oct;9(5):447-53. RECENT FINDINGS: Ocular hypersensitivity reactions to different types of preservatives in different chemical classes of topical ophthalmic treatments reviewed in the literature include IgE-mast cell mediated, cell mediated and toxic. Quaternary ammoniums (benzalkonium chloride) are most commonly (8% reported cases in OVID and PubMED based searches) associated with irritant toxic reactions whereas the organomercurials (thimerosal) and the (chlorobutanol) have the highest association (19% of OVID and 14% of PubMED based searches and 20% of OVID and 11% of PubMED searches), respectively, with allergic responses although the term allergy for the appears to be actually an irritant effect whereas the organomercurials appear to truly interact with the immune system as neoantigens. |
1(0,0,0,1) | Details |
| 7173980 | Coleman JW: Neuraminidase- and benzalkonium chloride-dependent inhibition of basic peptide-induced rat mast cell secretion. Immunol Lett. 1982 Oct;5(4):197-201. Pretreatment of rat peritoneal mast cells with Vibrio comma neuraminidase, an enzyme which cleaves from oligosaccharides, led to inhibition of release induced by the basic peptides polylysine, corticotropin 1-24 and a decapeptide sequence of human IgE. |
1(0,0,0,1) | Details |
| 10353312 | Manetz TS, Meade BJ: Development of a flow cytometry assay for the identification and differentiation of chemicals with the potential to elicit irritation, IgE-mediated, or T cell-mediated hypersensitivity responses. Toxicol Sci. 1999 Apr;48(2):206-17. Therefore, using the endpoints of percent ear swelling, percent B220+ cells, and percent IgE+B220+ cells, a combined irritancy/phenotypic analysis assay was developed and tested with tetradecane (irritant), toluene diisocyanate, trimellitic anhydride (IgE-mediated allergens), benzalkonium chloride, dinitrofluorobenzene, oxazolone, and dinitrochlorobenzene (T cell-mediated allergens) over a range of concentrations. |
86(1,1,1,6) | Details |
| 15379788 | Larsen ST, Hansen R, Poulsen OM, Nielsen GD: Adjuvant effect of benzalkonium chloride on the allergen-specific IgE, IgG1 and IgG2a antibody formation in BALB/cJ mice. Basic Clin Pharmacol Toxicol. 2004 Aug;95(2):94-6. |
6(0,0,1,1) | Details |
| 11239931 | Lau AH, Chow SS, Ng YS: Immunologically induced release from rat peritoneal mast cells is enhanced by low levels of substance P. Eur J Pharmacol. 2001 Mar 2;414(2-3):295-303. We hence investigated if substance P would modulate immunologic activation of mast cells by studying the effect of the neuropeptide on anti-rat immunologlobulin E antibody (anti-IgE)-induced release from purified rat peritoneal mast cells. While the potentiating effect of substance P was not suppressed by any of the non-peptide tachykinin receptor antagonists CP99994 ((2S,3S)-3-(2-methoxybenzylamino)-2-phenylpiperidine), SR48968 ((S)-N-methyl-N-(4-acetylamino-4-phenylpiperidino)-2-(3,4-dichlorophenyl) butyl-benzamide) and SR142801 ((S)-(N)-(1-[3-(1-benzoyl-3 (3,4-dichlorophenyl) piperidine-3-yl) propyl]-4-p henylpiperidin-4-yl)-N-methyl-acetamide), it was mimicked by compound 48/80 and suppressed by benzalkonium chloride. |
3(0,0,0,3) | Details |