| Name | caspase 3 |
|---|---|
| Synonyms | Apopain; CASP 3; CASP3; CPP 32; CPP32; CPP32B; Caspase 3; Caspase 3 precursor… |
| Name | lindane |
|---|---|
| CAS | (1α,2α,3β,4α,5α,6β)-1,2,3,4,5,6-hexachlorocyclohexane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 20036686 | Sharma H, Zhang P, Barber DS, Liu B: Organochlorine pesticides dieldrin and lindane induce cooperative toxicity in dopaminergic neurons: role of oxidative stress. Neurotoxicology. 2010 Mar;31(2):215-22. Epub 2009 Dec 29. Mechanistically, dieldrin and lindane combination induced a rapid increase in the levels of intracellular reactive species, a decrease in mitochondrial membrane potential and activation of caspase 3/7. |
81(1,1,1,1) | Details |
| 19038305 | Saradha B, Vaithinathan S, Mathur PP: Lindane induces testicular apoptosis in adult Wistar rats through the involvement of Fas-FasL and mitochondria-dependent pathways. Toxicology. 2009 Jan 31;255(3):131-9. Epub 2008 Nov 5. To elucidate the mechanism (s) underpinning the gonadal effects of lindane, we sought to investigate the levels of apoptosis-related proteins, namely cytochrome c, caspase-3 and-9, Fas and FasL in the testis of adult rats. |
33(0,1,1,3) | Details |
| 19221147 | La Sala G, Farini D, De Felici M: Proapoptotic effects of lindane on mouse primordial germ cells. Toxicol Sci. 2009 Apr;108(2):445-51. Epub 2009 Feb 16. Further experiments showed that in such model, lindane induced features of apoptotic cell death in PGCs such as increase in caspase-3 activity, poly-ADP- polymerase cleavage, and terminal nick-end labeling (TUNEL) positivity. |
31(0,1,1,1) | Details |
| 19175174 | Liang XM, Hu YF, Yu HG, Yang KD: [Effects of p,p'-DDE and beta-BHC on the apoptosis of Sertoli cells in vitro]. Zhonghua Yu Fang Yi Xue Za Zhi. 2008 Sep;42(9):648-52. The inhibitory group was first treated with 100 micromol/L Caspase-3 inhibitor Ac-DEVD-CHO treating for 2 hours before 50 micromol/L p, p'-DDE + 50 micromol/L beta-BHC 24 hours-treatment. |
4(0,0,0,4) | Details |
| 19818741 | Srivastava A, Shivanandappa T: Stereospecificity in the cytotoxic action of hexachlorocyclohexane isomers. Chem Biol Interact. 2010 Jan 5;183(1):34-9. Epub . HCH lead to apoptotic as well as necrotic cell death as it was marked by increased caspase-3 activity and lactate dehydrogenase (LDH) leakage, respectively. |
1(0,0,0,1) | Details |