Protein Information

Name SP4
Synonyms HF1B; SP4; SPR 1; Sp4 transcription factor; Transcription factor Sp4; Sp4 transcription factors; Transcription factor Sp4s

Compound Information

Name benzalkonium chloride
CAS quaternary ammonium compounds, alkylbenzyldimethyl, chlorides

Reference List

PubMed Abstract RScore(About this table)
2444699 Repke H, Piotrowski W, Bienert M, Foreman JC: Histamine release induced by Arg-Pro-Lys-Pro (CH2) 11CH3 from rat peritoneal mast cells. J Pharmacol Exp Ther. 1987 Oct;243(1):317-21.

Unlike dodecylamine itself, SP1-4C12 induced noncytolytic histamine release which was inhibited by benzalkonium chloride and by the substance P antagonist [D-Pro4,D-Trp7,9,10] SP4-11.
81(1,1,1,1) Details
2417614 Piotrowski W, Foreman JC: Some effects of calcitonin gene-related peptide in human skin and on histamine release. Br J Dermatol. 1986 Jan;114(1):37-46.

The substance P analogue, [D-Pro4, D-Trp7,9,10] SP4-11 10 microM, and benzalkonium chloride 10 microM inhibited histamine release from rat mast cells stimulated by either CGRP or substance P.
31(0,1,1,1) Details
2419771 Piotrowski W, Foreman JC: On the actions of substance P, somatostatin, and vasoactive intestinal polypeptide on rat peritoneal mast cells and in human skin. Naunyn Schmiedebergs Arch Pharmacol. 1985 Dec;331(4):364-8.

The release of histamine induced by these neuropeptides was inhibited by preincubation of the cells with the SP analogue [D-Pro4,D-Trp7,9,10]-SP4-11 (SP-A) (10 microM), and also by benzalkonium chloride (10 microM).
31(0,1,1,1) Details
2440265 Piotrowski W, Mead M, Foreman JC: Action of the SP2-11 and SP3-11 fragments of substance P on rat peritoneal mast cells. Agents Actions. 1987 Apr;20(3-4):178-80.

The substance P antagonist [D-Pro4, D-Trp7,9,10] SP4-11 was equally effective at antagonizing the histamine releasing action of SP1-11, SP2-11 and SP3-11.
Benzalkonium chloride was found to be a competitive antagonist of SP and SP3-11: the dissociation constants for the benzalkonium chloride-receptor interaction being about the same when either SP1-11 or SP3-11 was used as the agonist.
1(0,0,0,1) Details