Protein Information

Name dopamine beta monooxygenase
Synonyms DBH; DBM; Dopamine beta hydroxylase; Dopamine beta monooxygenase; Dopamine beta hydroxylase precursor; dopamine beta hydroxylase (dopamine beta monooxygenase); DBH; Dopamine beta hydroxylases…

Compound Information

Name copper sulfate
CAS sulfuric acid copper(2+) salt (1:1)

Reference List

PubMed Abstract RScore(About this table)
3805036 Ahn NG, Klinman JP: Activation of dopamine beta-monooxygenase by external and internal electron donors in resealed chromaffin granule ghosts. J Biol Chem. 1987 Feb 5;262(4):1485-92.

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2994573 Glembotski CC: Further characterization of the peptidyl alpha-amidating enzyme in rat anterior pituitary secretory granules. Arch Biochem Biophys. 1985 Sep;241(2):673-83.


Because of the requirement for peptides with COOH-terminal glycine residues, and cofactor requirements similar to monooxygenases such as dopamine beta-monooxygenase, we have proposed that the alpha-amidating enzyme be named peptidylglycine alpha-amidating monooxygenase, or PAM.
1(0,0,0,1) Details
7260097 Skotland T: Studies on the interaction of Cibacron Blue and Procion Red with dopamine beta-monooxygenase. Biochim Biophys Acta. 1981 Jun 15;659(2):312-25.

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6271712 Ahmed T, Januszkiewicz A, Eyre P, Robinson MJ, Sackner MA: Acute pulmonary hemodynamic effects of intravenous copper sulfate: role of alpha-adrenergic system. J Appl Physiol. 1981 Nov;51(5):1204-13.

Serum dopamine beta-hydroxylase increased from 3.2 U/l before CuSO4 injection to 5.7 after its administration, signifying activation of adrenergic nervous system.
1(0,0,0,1) Details