Protein Information

Name immunoglobulin (protein family or complex)
Synonyms Immunoglobulin; Immunoglobulins

Compound Information

Name copper sulfate
CAS sulfuric acid copper(2+) salt (1:1)

Reference List

PubMed Abstract RScore(About this table)
9726426 Rowe DB, Le W, Smith RG, Appel SH: Antibodies from patients with Parkinson's disease react with protein modified by dopamine oxidation. J Neurosci Res. 1998 Sep 1;53(5):551-8.

To determine whether specific antibodies are present in PD, we used an enzyme-linked immunosorbant assay (ELISA) that identifies increased immunoglobulin (IgG) levels towards a synthetic substrate prepared by incubating ovalbumin with dopamine and copper sulfate.
82(1,1,1,2) Details
6965944 Lipsky PE, Ziff M: Inhibition of human helper T cell function in vitro by D-penicillamine and CuSO4. J Clin Invest. 1980 May;65(5):1069-76.

The effect of d-penicillamine (Pen) and mixtures of Pen and copper sulfate on the capacity of normal human peripheral blood mononuclear cells (PBM) to generate immunoglobulin-secreting cells (ISC) in response to the T-cell-dependent polyclonal B-cell activators pokeweed mitogen (PWM) and staphylococcal protein A (SPA) was examined.
31(0,1,1,1) Details
18598667 Wei X, Liang A, Zhang SS, Jiang ZL: A selective resonance scattering assay for immunoglobulin G using Cu (II)-ascorbic acid-immunonanogold reaction. Anal Biochem. 2008 Sep 15;380(2):223-8. Epub 2008 Jun 13.

2(0,0,0,2) Details
3630482 Potemkina EE, Galkina LV, Khrometskaia TM, Krylova EE, Mamaeva TA: [Possibility of decreasing the anticomplement activity of human immunoglobulin preparations via chemical modification]. Zh Mikrobiol Epidemiol Immunobiol. 1987 Jun;(6):54-7.

2(0,0,0,2) Details
6971939 Lipsky PE: Modulation of human antibody production in vitro by D-penicillamine and CuSO4: inhibition of helper T cell function. J Rheumatol Suppl. 1981 Jan-Feb;7:69-73.


Pokeweed mitogen (PWM), a T cell dependent, polyclonal B cell activator, stimulates the differentiation of immunoglobulin secreting cells (ISC) from normal human peripheral blood mononuclear cells (PBM).
1(0,0,0,1) Details