| Name | thrombin |
|---|---|
| Synonyms | Coagulation factor II; Coagulation factor II variant; F2; F2 protein; F2 protein precursor; Factor II; PT; Prothrombin… |
| Name | copper sulfate |
|---|---|
| CAS | sulfuric acid copper(2+) salt (1:1) |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9777653 | Mahfouz MM, Kummerow FA: Oxysterols and TBARS are among the LDL oxidation products which enhance synthesis by platelets. Prostaglandins Other Lipid Mediat. 1998 Jul;56(4):197-217. In this study, we compared the effects of normal LDL (nLDL) and oxidized LDL (oxLDL) on release by platelets triggered by low concentration of thrombin, and we determined which component of oxLDL is responsible for that activation. After oxidation of LDL with copper sulfate, the small molecular weight fraction (< 10 kDa) which was high in TBARS was removed; using Amicon Centriprep-10 concentrator membrane. |
3(0,0,0,3) | Details |
| 10938412 | Mahfouz MM, Kummerow FA: Oxidized low-density lipoprotein (LDL) enhances A (2) synthesis by platelets, but lysolecithin as a product of LDL oxidation has an inhibitory effect. Prostaglandins Other Lipid Mediat. 2000 Jul;62(2):183-200. Oxidation of low-density lipoprotein (LDL) by copper sulfate led to a significant increase in lysophosphatidylcholine (lyso PC) at the expense of Platelets incubated with various concentrations of lyso PC (2-100 microM) for 5 or 15 min and then triggered with thrombin also showed a significant decrease of A (2) (TXA (2)) release as lyso PC concentration reached 10 microM or 6 microM, respectively. |
3(0,0,0,3) | Details |
| 9183639 | Kishimoto T, Oguri T, Ueda D, Tada M: enhances EDNO (endothelium-derived activity by cultured human vascular endothelial cells. Hum Cell. 1996 Jun;9(2):117-24. The effect of copper sulfate (Cu) on viable cell number, endothelium-derived (EDNO), and synthase (NOS) in cultured human umbilical vascular endothelial cells (HUVEC) was investigated. Thrombin (0.05 units/ml)-induced platelet aggregation was markedly inhibited in the presence of HUVEC compared with aggregation in the absence of HUVEC. |
2(0,0,0,2) | Details |