Protein Information

Name cholinesterase
Synonyms Acylcholine acylhydrolase; BCHE; BCHE protein; Butyrylcholine esterase; Butyrylcholinesterase; CHE1; Choline esterase II; Cholinesterase…

Compound Information

Name famphur
CAS

Reference List

PubMed Abstract RScore(About this table)
7447135 Randell WF, Bradley RE: Effects of injectable famphur on young Brahman and Angus cattle. Am J Vet Res. 1980 Sep;41(9):1423-6.

In a subsequent trial, clinical and cholinesterase responses were monitored in young Brahman bulls, steers, and heifers given famphur at different dosages.
7(0,0,1,2) Details
94259 Hart RJ, Cavey WA, Moore B, Strong MB: Efficiency and safety of methidathion applied as a pour-on systemic insecticide for control of cattle lice. Aust Vet J. 1979 Dec;55(12):575-9.

Treatment with fenthion at 50 mg/kg, 7.4 times the average recommended rate, famphur at 75 mg/kg, 3 times the average rate and chlorpyrifos at 85 mg/kg, 5 times average rate, caused reductions in whole blood cholinesterase activity of 52%, 27% and 47% respectively which were similar to the reductions in cholinesterase activity found in calves treated with methidathion at similar levels above the recommended commercial dose rates.
6(0,0,1,1) Details
7284948 Watson K, Black WD: Whole blood cholinesterase activity in calves after topical treatment with famphur. Can Vet J. 1981 Jun;22(6):179-81.
6(0,0,1,1) Details
15253053 Fleischli MA, Franson JC, Thomas NJ, Finley DL, Riley W Jr: Avian mortality events in the United States caused by anticholinesterase pesticides: a retrospective summary of National Wildlife Health Center records from 1980 to 2000. Arch Environ Contam Toxicol. 2004 May;46(4):542-50.

Of 24 different pesticides identified, the most frequent were famphur (n = 59: 18%), carbofuran (n = 52; 15%), diazinon (n = 40; 12%), and fenthion (n = 17; 5.1%).
3(0,0,0,3) Details
2716098 White DH, Hayes LE, Bush PB: Case histories of wild birds killed intentionally with famphur in Georgia and West Virginia. J Wildl Dis. 1989 Apr;25(2):184-8.

However, severe depression of cholinesterase activity was evident in brains of birds found dead, suggesting gross exposure to an organophosphorus (OP) or carbamate pesticide.
1(0,0,0,1) Details
10690770 Braselton WE, Johnson JL, Carlson MP, Schneider NR: Gas chromatography/mass spectrometry identification and quantification of isazophos in a famphur pour-on and in bovine tissues after a toxic exposure. J Vet Diagn Invest. 2000 Jan;12(1):15-20.

A product formulation problem was suspected because brain cholinesterase activities were depressed in both animals.
1(0,0,0,1) Details
3586207 Henny CJ, Kolbe EJ, Hill EF, Blus LJ: Case histories of bald eagles and other raptors killed by organophosphorus insecticides topically applied to livestock. J Wildl Dis. 1987 Apr;23(2):292-5.

Since 1982 when secondary poisoning of a red-tailed hawk (Buteo jamaicensis) was documented following the recommended use of famphur applied topically to cattle, the Patuxent Wildlife Research Center has tested dead birds of prey for poisoning by famphur and other pour-on organophosphorus (OP) insecticides.
Brain cholinesterase (ChE) activity was first determined, then if ChE was depressed greater than or equal to 50%, stomach and/or crop contents were evaluated for anti-ChE compounds.
1(0,0,0,1) Details
7272837 Khan MA, Kozub GC: Systemic control of cattle grubs (Hypoderma spp.) in steers treated with Warbex and weight gains associated with grub control. Can J Comp Med. 1981 Jan;45(1):15-9.


When applied to yearling steers on November 30, pour-on applications of famphur at 40 or 50 mg/kg were unsatisfactory for systemic grub control as they only reduced the number of warble grubs by 52.2 and 68.4%, respectively.
0(0,0,0,0) Details