Protein Information

Name novel protein
Synonyms FAM89A; Novel protein; RP11 423F24.2

Compound Information

Name cycloheximide
CAS

Reference List

PubMed Abstract RScore(About this table)
19118520 Yamauchi A, Takahashi I, Takasawa S, Nata K, Noguchi N, Ikeda T, Yoshikawa T, Shervani NJ, Suzuki I, Uruno A, Unno M, Okamoto H, Sugawara A: Thiazolidinediones inhibit REG Ialpha gene transcription in gastrointestinal cancer cells. Biochem Biophys Res Commun. 2009 Feb 13;379(3):743-8. Epub 2008 Dec 30.

The TZD-induced REG Ialpha mRNA reduction was abolished by cycloheximide, indicating the necessity of novel protein (s) synthesis.
81(1,1,1,1) Details
17726147 Jorgensen JA, Zadravec D, Jacobsson A: Norepinephrine and rosiglitazone synergistically induce Elovl3 expression in brown adipocytes. Am J Physiol Endocrinol Metab. 2007 Nov;293(5):E1159-68. Epub 2007 Aug 28.


The maximal increase in mRNA level by norepinephrine and rosiglitazone is achieved by induced transcription as well as increased mRNA stability, and the whole process requires novel protein synthesis.
1(0,0,0,1) Details
15528187 Zhang X, Kolaczkowska A, Devaux F, Panwar SL, Hallstrom TC, Jacq C, Moye-Rowley WS: Transcriptional regulation by Lge1p requires a function independent of its role in histone H2B ubiquitination. J Biol Chem. 2005 Jan 28;280(4):2759-70. Epub 2004 Nov 4.


We identify the novel protein Lge1p as a required participant in the rho (0) activation of PDR3 and PDR5 expression.
1(0,0,0,1) Details
16141313 Tian Q, Li J, Xie X, Sun M, Sang H, Zhou C, An T, Hu L, Ye RD, Wang MW: Stereospecific induction of nuclear factor-kappaB activation by isochamaejasmin. Mol Pharmacol. 2005 Dec;68(6):1534-42. Epub 2005 Sep 1.

Isochamaejasmin also induced time-dependent phosphorylation of the mitogen-activated protein kinases extracellular signal-regulated kinase 1/2 and p38, and a novel protein kinase C (PKCdelta).
It is noteworthy that the two stereoisomers and the methyl derivative did not induce detectable activation of NF-kappaB and were more cytotoxic than isochamaejasmin, which could partially rescue cycloheximide-induced apoptosis.
1(0,0,0,1) Details