Protein Information

Name apolipoprotein
Synonyms APOA 2; APOA2; APOAL; APOARGC; Apolipoprotein; Apolipoprotein (A) related gene C; Apolipoprotein (a); Apolipoprotein A II…

Compound Information

Name copper sulfate
CAS sulfuric acid copper(2+) salt (1:1)

Reference List

PubMed Abstract RScore(About this table)
12729008 Arai H, Uchida K, Fukunaga K, Nagasaka Y, Mohri S, Furumoto H, Kuramitsu Y, Nakamura K: Effect of alpha-tocopherol on the oxidative modification of apolipoprotein E in human very-low-density lipoprotein. Biosci Biotechnol Biochem. 2003 Feb;67(2):402-5.


The oxidative modification of apolipoprotein (apo) E and lipid peroxidation in human very-low-density lipoprotein (VLDL) induced by peroxynitrite and cupric ions in vitro were strongly suppressed by enrichment with alpha-tocopherol (alpha-Toc; 170 microM).
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11590223 Edelstein C, Nakajima K, Pfaffinger D, Scanu AM: Oxidative events cause degradation of apoB-100 but not of apo [a] and facilitate enzymatic cleavage of both proteins. J Lipid Res. 2001 Oct;42(10):1664-70.


Lipoprotein [a] (Lp [a]) contains equimolar amounts of apoB-100 and apolipoprotein [a] (apo [a]).
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9554802 Hayek T, Attias J, Smith J, Breslow JL, Keidar S: Antiatherosclerotic and antioxidative effects of captopril in apolipoprotein E-deficient mice. J Cardiovasc Pharmacol. 1998 Apr;31(4):540-4.


The effect of the angiotensin-converting enzyme (ACE) inhibitor, captopril, on the development of atherosclerosis was determined in the apolipoprotein (apo) E-deficient mice.
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9166989 Napoli C, Triggiani M, Palumbo G, Condorelli M, Chiariello M, Ambrosio G: Glycosylation enhances oxygen radical-induced modifications and decreases acetylhydrolase activity of human low density lipoprotein. Basic Res Cardiol. 1997 Apr;92(2):96-105.


Oxidation of glc-LDL also induced a higher degree of apolipoprotein-B100 modifications than n-LDL, with increased electrophoresis mobility and decreased TNBS reactivity.
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11200090 Malminiemi K, Palomaki A, Malminiemi O: Comparison of LDL trap assay to other tests of antioxidant capacity; effect of vitamin E and lovastatin treatment. Free Radic Res. 2000 Nov;33(5):581-93.


TRAP correlated with the lag time (r = 0.55, p < 0.001) and alpha-TOH consumption time (r = 0.48, p < 0.05), and inversely with apolipoprotein Al (r = -0.51, p < 0.05).
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9245700 Keidar S, Attias J, Smith J, Breslow JL, Hayek T: The angiotensin-II receptor antagonist, losartan, inhibits LDL lipid peroxidation and atherosclerosis in apolipoprotein E-deficient mice. Biochem Biophys Res Commun. 1997 Jul 30;236(3):622-5.


The potential antiatherogenic actions of the angiotensin II receptor antagonist, losartan were investigated in apolipoprotein (apo) E deficient mice, an animal model with severe hypercholesterolemia and extensive atherosclerosis.
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