| Name | kinase suppressor of Ras 1 |
|---|---|
| Synonyms | KSR; KSR 1; KSR1; Kinase suppressor of ras; Kinase suppressor of ras 1; RSU 2; RSU2; Kinase suppressor of ras 1s |
| Name | cycloheximide |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17613518 | McKay MM, Morrison DK: Caspase-dependent cleavage disrupts the ERK cascade scaffolding function of KSR1. J Biol Chem. 2007 Sep 7;282(36):26225-34. Epub 2007 Jul 5. In addition, we find that in comparison with KSR1 (-/-) mouse embryonic fibroblasts expressing wild type KSR1 (WT-KSR1), cells expressing a cleavage-resistant KSR1 protein (DEVA-KSR1) exhibit reduced apoptotic signaling in response to tumor necrosis factor-alpha/cycloheximide treatment. |
89(1,1,1,9) | Details |
| 15684389 | Salerno M, Palmieri D, Bouadis A, Halverson D, Steeg PS: Nm23-H1 metastasis suppressor expression level influences the binding properties, stability, and function of the kinase suppressor of Ras1 (KSR1) Erk scaffold in breast carcinoma cells. Mol Cell Biol. 2005 Feb;25(4):1379-88. Cells expressing high levels of Nm23-H1 exhibited increased KSR1 degradation in the presence of either cycloheximide or an Hsp90-directed drug currently in clinical trial, 17-allylamino-17-demethoxygeldanamycin (17-AAG). |
87(1,1,1,7) | Details |
| 16732322 | Wang X, Wang TT, White JH, Studzinski GP: Induction of kinase suppressor of RAS-1 (KSR-1) gene by 1, alpha25- in human leukemia HL60 cells through a response element in the 5'-flanking region. Oncogene. 2006 Nov 9;25(53):7078-85. Epub 2006 May 29. Further, the upregulation of KSR-1 gene by 1,25D is competed by ZK159222, an antagonist of receptor (VDR) action, and can occur in the presence of protein synthesis inhibitor cycloheximide, showing that the effect is direct. |
0(0,0,0,0) | Details |