| Name | elastin |
|---|---|
| Synonyms | ELN; WS; WBS; Elastin; Elastin precursor; SVAS; Tropoelastin; Elastins… |
| Name | cycloheximide |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19844261 | Micale L, Turturo MG, Fusco C, Augello B, Jurado LA, Izzi C, Digilio MC, Milani D, Lapi E, Zelante L, Merla G: Identification and characterization of seven novel mutations of elastin gene in a cohort of patients affected by supravalvular aortic stenosis. Eur J Hum Genet. 2010 Mar;18(3):317-23. Epub 2009 Oct 21. In vitro analysis using minigenes and cycloheximide showed that some selected frameshift mutant alleles are substrates of nonsense-mediated mRNA decay (NMD), confirming that the functional haploinsufficiency of the ELN gene is the main pathomechanism underlying SVAS. |
84(1,1,1,4) | Details |
| 17209135 | Kuang PP, Zhang XH, Rich CB, Foster JA, Subramanian M, Goldstein RH: Activation of elastin transcription by transforming growth factor-beta in human lung fibroblasts. Am J Physiol Lung Cell Mol Physiol. 2007 Apr;292(4):L944-52. Epub 2007 Jan 5. The induction of elastin hnRNA and mRNA expression by TGF-beta was abolished by pretreatments with TGF-beta receptor I inhibitor, global transcription inhibitor actinomycin D, and partially blocked by addition of protein synthesis inhibitor cycloheximide, but was not affected by the p44/42 MAPK inhibitor U0126. |
7(0,0,0,7) | Details |
| 16411808 | Engbers-Buijtenhuijs P, Buttafoco L, Poot AA, Geelkerken RH, Feijen J, Vermes I: Analysis of the balance between proliferation and apoptosis of cultured vascular smooth muscle cells for tissue-engineering applications. Tissue Eng. 2005 Nov-Dec;11(11-12):1631-9. Human vascular smooth muscle cells (VSMCs) were cultured either on gelatin-coated tissue culture polystyrene or in three-dimensional porous scaffolds composed of insoluble collagen and elastin. mRNA concentrations of cyclin E, as a marker of proliferation, and of tissue transglutaminase (tTG) as a marker of apoptosis, quantified by a real-time reverse transcriptase-polymerase chain reaction (RT-PCR) and normalized to porphobilinogen deaminase mRNA concentrations, were analyzed. tTG mRNA expression levels were increased when apoptosis was induced by tumor necrosis factor-alpha in combination with cycloheximide or by culturing the cells in serum-free culture medium. |
6(0,0,1,1) | Details |
| 15814588 | Kuang PP, Goldstein RH: Regulation of elastin gene transcription by proteasome dysfunction. Am J Physiol Cell Physiol. 2005 Sep;289(3):C766-73. Epub 2005 Apr 6. Addition of cycloheximide blocked these increases and the downregulation of elastin mRNA by MG-132. |
90(1,1,1,10) | Details |