Protein Information

Name adiponectin
Synonyms 30 kDa adipocyte complemen related protein; 30 kDa adipocyte complement related protein; ACDC; ACRP30; ADIPOQ; APM 1; APM1; Adipocyte C1Q and collagen domain containing…

Compound Information

Name cycloheximide
CAS

Reference List

PubMed Abstract RScore(About this table)
15939809 Clasen R, Schupp M, Foryst-Ludwig A, Sprang C, Clemenz M, Krikov M, Thone-Reineke C, Unger T, Kintscher U: PPARgamma-activating angiotensin type-1 receptor blockers induce adiponectin. Hypertension. 2005 Jul;46(1):137-43. Epub 2005 Jun 6.

Kinetic studies using the protein synthesis inhibitor cycloheximide showed that irbesartan prevented the cellular depletion of adiponectin protein.
40(0,1,1,10) Details
16325814 Yamaguchi N, Argueta JG, Masuhiro Y, Kagishita M, Nonaka K, Saito T, Hanazawa S, Yamashita Y: Adiponectin inhibits Toll-like receptor family-induced signaling. FEBS Lett. 2005 Dec 19;579(30):6821-6. Epub 2005 Nov 28.

Therefore, in the present study, we investigated whether globular adiponectin (gAd) would be able to inhibit TLR-mediated nuclear factor-kappaB (NF-kappaB) signaling in mouse macrophages (RAW264). gAd predominantly bound to the AdipoR1 receptor and suppressed TLR-mediated NF-kappaB signaling. gAd-mediated inhibition of TLR-mediated IkappaB phosphorylation and NF-kappaB activation was eliminated by the pretreatment of cycloheximide.
34(0,1,1,4) Details
17353260 Wang ZV, Schraw TD, Kim JY, Khan T, Rajala MW, Follenzi A, Scherer PE: Secretion of the adipocyte-specific secretory protein adiponectin critically depends on thiol-mediated protein retention. Mol Cell Biol. 2007 May;27(10):3716-31. Epub 2007 Mar 12.

8(0,0,0,8) Details
16407204 Xie L, Boyle D, Sanford D, Scherer PE, Pessin JE, Mora S: Intracellular trafficking and secretion of adiponectin is dependent on GGA-coated vesicles. J Biol Chem. 2006 Mar 17;281(11):7253-9. Epub 2005 Dec 29.

7(0,0,0,7) Details