Protein Information

Name serum glucocorticoid regulated kinase
Synonyms SGK; SGK 1; SGK1; Serine/threonine protein kinase SGK; Serine/threonine protein kinase SGK1; Serum and glucocorticoid regulated kinase; Serum/glucocorticoid regulated kinase; Serum/glucocorticoid regulated kinase 1…

Compound Information

Name cycloheximide
CAS

Reference List

PubMed Abstract RScore(About this table)
15536167 Boyd C, Naray-Fejes-Toth A: Gene regulation of ENaC subunits by serum- and glucocorticoid-inducible kinase-1. Am J Physiol Renal Physiol. 2005 Mar;288(3):F505-12. Epub 2004 Nov 9.


The goal of this study was to examine whether serum- and glucocorticoid-inducible kinase-1 (SGK1), an aldosterone-induced gene, is vital to the delayed effect of aldosterone by increasing the gene expression of ENaC subunits.
9(0,0,0,9) Details
18615584 Vasquez MM, Castro R, Seidner SR, Henson BM, Ashton DJ, Mustafa SB: Induction of serum- and glucocorticoid-induced kinase-1 (SGK1) by cAMP regulates increases in alpha-ENaC. J Cell Physiol. 2008 Dec;217(3):632-42.

6(0,0,0,6) Details
16971495 Wang D, Zhang H, Lang F, Yun CC: Acute activation of NHE3 by dexamethasone correlates with activation of SGK1 and requires a functional glucocorticoid receptor. Am J Physiol Cell Physiol. 2007 Jan;292(1):C396-404. Epub 2006 Sep 13.

Chronic regulation (24 h) of NHE3 was blocked completely by prevention of protein synthesis with cycloheximide or actinomycin D and by the glucocorticoid receptor blocker RU486.
6(0,0,0,6) Details
16787409 Ravni A, Eiden LE, Vaudry H, Gonzalez BJ, Vaudry D: Cycloheximide treatment to identify components of the transitional transcriptome in PACAP-induced PC12 cell differentiation. J Neurochem. 2006 Aug;98(4):1229-41. Epub 2006 Jun 19.

Five out of the six transcripts were indeed induced by PACAP alone soon (between 30 min and 3 h) after cell treatment. beta-Cell translocation gene 2, antiproliferative (Btg2), serum/glucocorticoid-regulated kinase (Sgk), nuclear factor for the kappa chain of B-cells (NFkappaB), seven in absentia homologue 2 (Siah2) and FBJ osteosarcoma related oncogene (Fos) showed a 2.5-200-fold induction by PACAP between 15 min and 3 h, and mRNA levels returned either to baseline or near baseline after 6 h.
1(0,0,0,1) Details