Protein Information

Name syndecan 4
Synonyms Amphiglycan; Ryudocan; Ryudocan core protein; SDC 4; SDC4; SYND 4; SYND4; Syndecan 4…

Compound Information

Name cycloheximide
CAS

Reference List

PubMed Abstract RScore(About this table)
15596055 Bortoff KD, Wagner WD: Reduced syndecan-4 expression in arterial smooth muscle cells with enhanced proliferation. Exp Mol Pathol. 2005 Feb;78(1):10-6.

Studies using cycloheximide to superinduce gene expression indicated transcriptional suppression of syndecan-4 in WC cells.
86(1,1,1,6) Details
16924669 Song SJ, Cool SM, Nurcombe V: Regulated expression of syndecan-4 in rat calvaria osteoblasts induced by fibroblast growth factor-2. J Cell Biochem. 2007 Feb 1;100(2):402-11.

This upregulation could be abrogated by pretreatment with the protein synthesis inhibitor cycloheximide, suggesting that the upregulation of syndecan-4 by FGF2 is not a primary response.
4(0,0,0,4) Details
16807246 Hayashida K, Johnston DR, Goldberger O, Park PW: Syndecan-1 expression in epithelial cells is induced by transforming growth factor beta through a PKA-dependent pathway. J Biol Chem. 2006 Aug 25;281(34):24365-74. Epub 2006 Jun 28.


Steady-state syndecan-1 mRNA was not increased by TGFbeta treatment and cycloheximide did not inhibit syndecan-1 induction by TGFbeta, indicating that TGFbeta induces syndecan-1 in a post-translational manner.
0(0,0,0,0) Details