| Name | cyclin |
|---|---|
| Synonyms | Cyclin; DNA polymerase delta auxillary protein; PCNA; Proliferating cell nuclear antigen; DNA polymerase delta auxillary proteins; Proliferating cell nuclear antigens |
| Name | cycloheximide |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15870436 | Van Dross R, Yao S, Asad S, Westlake G, Mays DJ, Barquero L, Duell S, Pietenpol JA, Browning PJ: Constitutively active K-cyclin/cdk6 kinase in Kaposi sarcoma-associated herpesvirus-infected cells. J Natl Cancer Inst. 2005 May 4;97(9):656-66. The half-life of K-cyclin and cyclin D2 proteins was determined by blocking protein synthesis with cycloheximide and measuring proteins in cell lysates by western blot analysis. |
40(0,1,1,10) | Details |
| 15964852 | Zhu H, Nie L, Maki CG: Cdk2-dependent Inhibition of p21 stability via a C-terminal cyclin-binding motif. J Biol Chem. 2005 Aug 12;280(32):29282-8. Epub 2005 Jun 17. |
4(0,0,0,4) | Details |
| 16407831 | Taube ME, Liu XW, Fridman R, Kim HR: TIMP-1 regulation of cell cycle in human breast epithelial cells via stabilization of p27 (KIP1) protein. Oncogene. 2006 May 18;25(21):3041-8. TIMP-1-mediated cell cycle arrest is associated with its downregulation of cyclin D (1) and upregulation of p27 (KIP1), resulting in inhibition of cyclin-dependent kinase activity necessary for phosphorylation of the tumor suppressor retinoblastoma protein. |
3(0,0,0,3) | Details |
| 18291653 | McCleland ML, O'Farrell PH: RNAi of mitotic cyclins in Drosophila uncouples the nuclear and centrosome cycle. Curr Biol. 2008 Feb 26;18(4):245-54. RESULTS: We developed an approach with RNA interference (RNAi) and real-time imaging to study cyclin contributions to the rapid syncytial divisions of Drosophila embryos. |
2(0,0,0,2) | Details |
| 17266789 | Toranzo GS, Bonilla F, Zelarayan L, Oterino J, Buhler MI: Activation of maturation promoting factor in Bufo arenarum oocytes: injection of mature cytoplasm and germinal vesicle contents. Zygote. 2006 Nov;14(4):305-16. Reinitiation of meiosis is regulated by maturation promoting factor (MPF), a complex of the cyclin-dependent kinase p34cdc2 and cyclin B. |
2(0,0,0,2) | Details |
| 18824564 | Royou A, McCusker D, Kellogg DR, Sullivan W: Grapes (Chk1) prevents nuclear CDK1 activation by delaying cyclin B nuclear accumulation. J Cell Biol. 2008 Oct 6;183(1):63-75. Epub 2008 Sep 29. |
2(0,0,0,2) | Details |
| 18671273 | Priyadarshini A, Basu D, Navneet AK, Bhattacharya A, Bhattacharya S, Maitra S, Bhattacharya S: Activation of both Mos and Cdc25 is required for G2-M transition in perch oocyte. Mol Reprod Dev. 2009 Mar;76(3):289-300. Resumption of meiosis from diplotene arrest during the first meiotic prophase in vertebrate oocytes is universally controlled by MPF, a heterodimer of Cdk1 and cyclin B. Cycloheximide inhibited MIH induced Mos expression and its phosphorylation, which in turn reduced Myt1 phosphorylation and GVBD. |
1(0,0,0,1) | Details |
| 17310991 | Feng Q, Sekula D, Muller R, Freemantle SJ, Dmitrovsky E: Uncovering residues that regulate cyclin D1 proteasomal degradation. . Oncogene. 2007 Aug 2;26(35):5098-106. Epub 2007 Feb 19. Eighteen lysines in cyclin D1 had single, double or multiple mutations engineered before transfection into BEAS-2B human bronchial epithelial (HBE) cells to evaluate stabilities after (RA) or cycloheximide treatments. Specific mutations stabilized cyclin D1, including substitutions of lysines surrounding the cyclin box domain that inhibited RA-mediated degradation and extended the cyclin D1 half-life. |
1(0,0,0,1) | Details |
| 20339118 | Montezano AC, Burger D, Paravicini TM, Chignalia AZ, Yusuf H, Almasri M, He Y, Callera GE, He G, Krause KH, Lambeth D, Quinn MT, Touyz RM: Reduced Oxidase 5 (Nox5) Regulation by Angiotensin II and Endothelin-1 Is Mediated via /Calmodulin-Dependent, Rac-1-Independent Pathways in Human Endothelial Cells. Circ Res. 2010 Mar 25. Effects were inhibited by actinomycin D and cycloheximide and blunted by calmidazolium and low extracellular Ca (2+) ([Ca (2+)] e). |
0(0,0,0,0) | Details |
| 17606477 | MacManus CF, Pettigrew J, Seaton A, Wilson C, Maxwell PJ, Berlingeri S, Purcell C, McGurk M, Johnston PG, Waugh DJ: Interleukin-8 signaling promotes translational regulation of cyclin D in androgen-independent prostate cancer cells. Mol Cancer Res. 2007 Jul;5(7):737-48. Epub 2007 Jul 2. Administration of recombinant human IL-8 induced a rapid, time-dependent increase in cyclin D1 expression in AIPC cells, a response attenuated by the translation inhibitor cycloheximide but not by the RNA synthesis inhibitor, actinomycin D. |
1(0,0,0,1) | Details |
| 19137541 | Rizzi F, Caccamo AE, Belloni L, Bettuzzi S: Clusterin is a short half-life, poly-ubiquitinated protein, which controls the fate of prostate cancer cells. J Cell Physiol. 2009 May;219(2):314-23. Inhibition of protein synthesis by cycloheximide showed that CLU half-life is less than 2 h. Following siRNA targeting all CLU mRNA variants, all protein products quickly disappeared, inducing cell cycle progression and higher expression of specific proliferation markers (i.e., H3 mRNA, PCNA, and cyclins A, B1, and D) as detected by RT-qPCR and Western blot. |
1(0,0,0,1) | Details |
| 15735718 | He G, Siddik ZH, Huang Z, Wang R, Koomen J, Kobayashi R, Khokhar AR, Kuang J: Induction of p21 by p53 following DNA damage inhibits both Cdk4 and Cdk2 activities. Oncogene. 2005 Apr 21;24(18):2929-43. The induced p21 binds to both the Cdk4/cyclin D and Cdk2/cyclin E complexes and inhibits both of their kinase activities. Conversely, inhibition of p21 induction by cycloheximide or by p21 gene deletion prevents DAP-induced inhibition of Cdk4 and Cdk2 activities. |
1(0,0,0,1) | Details |
| 15897232 | Sakao S, Taraseviciene-Stewart L, Lee JD, Wood K, Cool CD, Voelkel NF: Initial apoptosis is followed by increased proliferation of apoptosis-resistant endothelial cells. FASEB J. 2005 Jul;19(9):1178-80. Epub 2005 May 16. Immunohistochemical staining for caspase-3 and PCNA and flow cytometry for Annexin-V and BrdU supported our concept, since SU5416 caused initial apoptosis (35.8% at 24 h after the SU5416 addition and 4.8% in control cells) whereas the surviving cells became hyperproliferative (PCNA positive). |
1(0,0,0,1) | Details |