Protein Information

Name corticotropin releasing factor
Synonyms CRF; CRH; Corticoliberin; Corticoliberin precursor; Corticotropin releasing factor; Corticotropin releasing hormone; Corticoliberins; Corticoliberin precursors…

Compound Information

Name cycloheximide
CAS

Reference List

PubMed Abstract RScore(About this table)
19747494 Nazzaro C, Barbieri M, Varani K, Beani L, Valentino RJ, Siniscalchi A: Swim stress enhances nociceptin/orphanin FQ-induced inhibition of rat dorsal raphe nucleus activity in vivo and in vitro: role of corticotropin releasing factor. Neuropharmacology. 2010 Feb;58(2):457-64. Epub 2009 Sep 9.

Stress-elicited potentiation involved corticotropin-releasing factor (CRF)(1) receptors, GABA signaling and protein synthesis, being attenuated by pre-treatment with antalarmin (20 mg/kg, i.p.), diazepam (2.4 mg/kg, i.p.) and cycloheximide (2.5 mg/kg, i.p.), respectively.
32(0,1,1,2) Details
17959175 Kaneko M, Okada R, Yamamoto K, Nakamura M, Mosconi G, Polzonetti-Magni AM, Kikuyama S: Bisphenol A acts differently from and independently of thyroid hormone in suppressing thyrotropin release from the bullfrog pituitary. Gen Comp Endocrinol. 2008 Feb 1;155(3):574-80. Epub 2007 Sep 19.

To this end, we exposed adult bullfrog (Rana catesbeiana) pituitary cells to BPA and/or TH in the presence or absence of corticotropin-releasing factor (CRF), which is known to have a potent TSH-releasing activity in amphibians.
A comparison of the suppressive effects of BPA and T (3) on the release of TSH following the addition of actinomycin D or cycloheximide to the culture medium revealed that both of the latter compounds blocked T (3)-inducible but not BPA-inducible suppression of TSH release.
1(0,0,0,1) Details