| Name | CREB |
|---|---|
| Synonyms | Active transcription factor CREB; CREB; CREB 1; CREB1; cAMP response element binding protein; cAMP response element binding protein 1; cAMP responsive element binding protein 1; cAMP responsive element binding protein 1 isoform B… |
| Name | cycloheximide |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17152074 | Misra UK, Pizzo SV: Upregulation of AKT1 protein expression in forskolin-stimulated macrophage: evidence from ChIP analysis that CREB binds to and activates the AKT1 promoter. J Cell Biochem. 2007 Mar 1;100(4):1022-33. |
5(0,0,0,5) | Details |
| 19244510 | Li S, Zhang C, Takemori H, Zhou Y, Xiong ZQ: TORC1 regulates activity-dependent CREB-target gene transcription and dendritic growth of developing cortical neurons. J Neurosci. 2009 Feb 25;29(8):2334-43. |
5(0,0,0,5) | Details |
| 15880467 | Kuramoto N, Kubo K, Ogita K, Platenik J, Balcar VJ, Takarada T, Nakamichi N, Yoneda Y: Nuclear condensation of cyclic responsive element-binding protein in discrete murine brain structures. J Neurosci Res. 2005 Jun 1;80(5):667-76. We have directed a polyclonal antibody against an oligo-peptide (123-136) of the transcription factor cyclic AMP responsive element-binding protein (CREB) including the serine residue at 133. Suppression of general new protein synthesis by cycloheximide (500 mg/kg, i.p.) in vivo resulted in a significant decrease in the nuclear CREB level, with a concomitant increase in the cytosolic level in hippocampus, but not in cerebellum. |
4(0,0,0,4) | Details |
| 17955499 | Shi L, Liu S, Nikolic D, Wang S: High glucose levels upregulate upstream stimulatory factor 2 gene transcription in mesangial cells. J Cell Biochem. 2008 Apr 15;103(6):1952-61. By using cycloheximide to block the de novo protein synthesis, similar rate of USF2 degradation was found under either normal or high conditions. By using the luciferase-promoter deletion assay, site-directed mutagenesis, and transactivation assay, we identified -responsive element in the USF2 gene promoter (-1,740 to -1,620, relative to the transcription start site) and demonstrated that -induced USF2 expression is mediated through a cAMP-response element-binding protein (CREB)-dependent transactivation of the USF2 promoter. |
3(0,0,0,3) | Details |
| 15604115 | Yeagley D, Quinn PG: 3',5'-cyclic adenosine monophosphate response element-binding protein and CCAAT enhancer-binding protein are dispensable for insulin inhibition of phosphoenolpyruvate carboxykinase transcription and for its synergistic induction by protein kinase A and glucocorticoids. Mol Endocrinol. 2005 Apr;19(4):913-24. Epub 2004 Dec 16. Here, we assessed the roles of CRE-binding protein (CREB) and C/EBP factors in mediating hormone-regulated transcription. Cycloheximide did not block insulin inhibition, indicating that alternate translation of C/EBPbeta is not required. |
2(0,0,0,2) | Details |
| 16197501 | Ghosh M, Gharami K, Paul S, Das S: Thyroid hormone-induced morphological differentiation and maturation of astrocytes involves activation of protein kinase A and ERK signalling pathway. Eur J Neurosci. 2005 Oct;22(7):1609-17. Moreover, the induction was accompanied by a parallel increase in phospho-CREB activity which, however, persisted at the end of the transformation of the astroglial cells. |
1(0,0,0,1) | Details |
| 16905344 | Kuo YM, Liang KC, Chen HH, Cherng CG, Lee HT, Lin Y, Huang AM, Liao RM, Yu L: Cocaine-but not methamphetamine-associated memory requires de novo protein synthesis. Neurobiol Learn Mem. 2007 Jan;87(1):93-100. Epub 2006 Aug 14. Taken together, these data suggest that protein synthesis and accumbal CREB phosphorylation are essential for the learning and consolidation of the cocaine-induced CPP, whereas methamphetamine-induced CPP may be unrelated to the synthesis of new proteins. Likewise, cocaine-induced CPP was mitigated by another protein synthesis inhibitor, cycloheximide (15 mg/kg/injection) pretreatment, whereas methamphetamine-induced CPP remained intact by such pretreatment. |
1(0,0,0,1) | Details |
| 17573545 | Periz G, Dharia D, Miller SH, Keller LR: Flagellar elongation and gene expression in Chlamydomonas reinhardtii. Eukaryot Cell. 2007 Aug;6(8):1411-20. Epub 2007 Jun 15. Li (+)-induced flagellar gene expression occurs in cells pretreated with cycloheximide, suggesting that the abundance change is a response that does not require new protein synthesis. Deletion analysis of the flagellar alpha1-tubulin gene promoter showed that sequences necessary for Li (+)-induced expression differed from those for acid shock induction and contain a consensus binding site for CREB/ATF and AP-1 transcription factors. |
1(0,0,0,1) | Details |
| 19470703 | Kanyo R, Price DM, Chik CL, Ho AK: Salt-inducible kinase 1 in the rat pinealocyte: adrenergic regulation and role in arylalkylamine N-acetyltransferase gene transcription. Endocrinology. 2009 Sep;150(9):4221-30. Epub 2009 May 21. The recognition of the basic zipper domain in the regulation of transcriptional activity of cAMP response element-binding protein by salt-inducible kinase (SIK) prompted our investigation of the regulatory role of this kinase in the induction of Aa-nat and other cAMP-regulated genes in the rat pineal gland. |
1(0,0,0,1) | Details |
| 16687308 | Simonneaux V, Sinitskaya N, Salingre A, Garidou ML, Pevet P: Rat and Syrian hamster: two models for the regulation of AANAT gene expression. Chronobiol Int. 2006;23(1-2):351-9. At the beginning of the night, (NE) elicits a rapid and sustained phosphorylation of CREB into pCREB and a transient synthesis of the immediate early gene products c-FOS and c-JUN that peak 3 h after dark onset. c-FOS synthesis requires both pCREB and the pERK1/2 pathways. Interestingly, injection of the protein synthesis inhibitor cycloheximide before, but not after, the c-FOS/c-JUN peak markedly reduces Aanat mRNA levels. |
1(0,0,0,1) | Details |
| 16299053 | Busch CJ, Liu H, Graveline AR, Bloch KD: induces phosphodiesterase 4B expression in rat pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2006 Apr;290(4):L747-L753. Epub 2005 Nov 18. The GSNO-induced increase of PDE4B gene expression is CREB dependent. The GSNO-induced increase in PDE4B mRNA levels was blocked by actinomycin D but augmented by cycloheximide. |
1(0,0,0,1) | Details |
| 15727843 | Huang NK, Cheng JJ, Lai WL, Lu MK: Antrodia camphorata prevents rat pheochromocytoma cells from serum deprivation-induced apoptosis. FEMS Microbiol Lett. 2005 Mar 1;244(1):213-9. On the other hand, A. camphorata also increased phosphorylated CREB, a transcription factor, which is H-89-inhibitable in this study, suggesting the possibility that A. camphorata prevents serum deprivation-induced PC12 cell apoptosis through a PKA/CREB-dependent pathway. |
1(0,0,0,1) | Details |
| 17140605 | Watatani Y, Kimura N, Shimizu YI, Akiyama I, Tonaki D, Hirose H, Takahashi S, Takahashi Y: Amino acid limitation induces expression of ATF5 mRNA at the post-transcriptional level. Life Sci. 2007 Feb 6;80(9):879-85. Epub 2006 Nov 11. ATF5 is a transcription factor in the cAMP response element (CRE)-binding protein/activating transcription factor (CREB/ATF) family. Cycloheximide inhibited the increase in ATF5 mRNA expression induced by limitation, indicating that it was dependent on de novo protein synthesis. |
1(0,0,0,1) | Details |
| 19843871 | Qi D, Cai K, Wang O, Li Z, Chen J, Deng B, Qian L, Le Y: Fatty acids induce amylin expression and secretion by pancreatic {beta}-cells. Am J Physiol Endocrinol Metab. 2009 Oct 20. Pretreatment of MIN6 cells with Ca (2+) chelator (EGTA, BAPTA/AM), protein kinase C (PKC) inhibitor Go6976, or protein synthesis inhibitor cycloheximide significantly inhibited FA-induced amylin mRNA expression. |
0(0,0,0,0) | Details |