Protein Information

Name CCAAT enhancer binding protein beta
Synonyms AGP/EBP; LAP; Alpha 1 acid glycoprotein/enhancer binding protein; C/EBP beta; CCAAT/enhancer binding protein beta; CEBPB; CRP 2; CRP2…

Compound Information

Name cycloheximide
CAS

Reference List

PubMed Abstract RScore(About this table)
16595698 Woltje M, Tschoke B, von Bulow V, Westenfeld R, Denecke B, Graber S, Jahnen-Dechent W: CCAAT enhancer binding protein beta and hepatocyte nuclear factor 3beta are necessary and sufficient to mediate dexamethasone-induced up-regulation of alpha2HS-glycoprotein/fetuin-A gene expression. J Mol Endocrinol. 2006 Apr;36(2):261-77.

2(0,0,0,2) Details
19411256 Liu R, Zheng HQ, Zhou Z, Dong JT, Chen C: KLF5 promotes breast cell survival partially through fibroblast growth factor-binding protein 1-pERK-mediated dual specificity MKP-1 protein phosphorylation and stabilization. J Biol Chem. 2009 Jun 19;284(25):16791-8. Epub 2009 May 1.

By cycloheximide chase assays, we found that KLF5 decreases MKP-1 protein degradation via activating the ERK signaling.
Krupple-like transcription factor 5 (KLF5) is a zinc-finger transcription factor promoting cell survival and tumorigenesis in multiple cancers.
1(0,0,0,1) Details
16452486 Seymour KJ, Roberts LE, Fini MA, Parmley LA, Oustitch TL, Wright RM: Stress activation of mammary epithelial cell xanthine oxidoreductase is mediated by p38 MAPK and CCAAT/enhancer-binding protein-beta. J Biol Chem. 2006 Mar 31;281(13):8545-58. Epub 2006 Feb 1.

Low dose cycloheximide stress promoted phosphorylation and nuclear accumulation of the CCAAT/enhancer-binding protein-beta (C/EBPbeta) transcription factor, which was blocked by inhibition of p38.
82(1,1,1,2) Details
17078024 Ejarque-Ortiz A, Medina MG, Tusell JM, Perez-Gonzalez AP, Serratosa J, Saura J: Upregulation of CCAAT/enhancer binding protein beta in activated astrocytes and microglia. Glia. 2007 Jan 15;55(2):178-88.

It is elicited by low concentrations of LPS (almost maximal effect at 1 ng/mL) and it is reversed by the protein synthesis inhibitor cycloheximide.
2(0,0,0,2) Details