| Name | Sphingosine kinase 1 |
|---|---|
| Synonyms | SK 1; SPK; SPHK; SPHK 1; SPHK1; SPHK1 protein; SPK 1; SPK1… |
| Name | cycloheximide |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16571380 | Huwiler A, Doll F, Ren S, Klawitter S, Greening A, Romer I, Bubnova S, Reinsberg L, Pfeilschifter J: increases sphingosine kinase-1 expression and activity in the human arterial endothelial cell line EA.hy 926 by a PKC-alpha-dependent mechanism. Biochim Biophys Acta. 2006 Mar;1761(3):367-76. Epub 2006 Mar 10. The increased SK-1 protein expression is due to stimulated de novo synthesis since cycloheximide inhibited the delayed SK-1 protein upregulation. |
89(1,1,1,9) | Details |
| 15855330 | Mastrandrea LD, Sessanna SM, Laychock SG: kinase activity and production in rat pancreatic islets and INS-1 cells: response to cytokines. Diabetes. 2005 May;54(5):1429-36. kinase (SPHK) and S1P were characterized in INS-1 insulinoma cells and isolated rat islets of Langerhans. Cytokines increased endogenous S1P biosynthesis in 32P (i)-prelabeled INS-1 cells, and cycloheximide inhibited the response after 8 h, suggesting that protein synthesis mediated the response. |
4(0,0,0,4) | Details |