Protein Information

Name E cadherin
Synonyms Arc 1; CAM 120/80; CD324; CD324 antigen; CDH 1; CDH1; CDHE; Cadherin 1…

Compound Information

Name cycloheximide
CAS

Reference List

PubMed Abstract RScore(About this table)
18787018 Adams BD, Claffey KP, White BA: Argonaute-2 expression is regulated by epidermal growth factor receptor and mitogen-activated protein kinase signaling and correlates with a transformed phenotype in breast cancer cells. Endocrinology. 2009 Jan;150(1):14-23. Epub 2008 Sep 11.


Half-life studies using cycloheximide indicated that EGF enhanced, whereas U0126 decreased, Ago2 protein stability.
0(0,0,0,0) Details
15574423 Yamada A, Irie K, Hirota T, Ooshio T, Fukuhara A, Takai Y: Involvement of the annexin II-S100A10 complex in the formation of E-cadherin-based adherens junctions in Madin-Darby canine kidney cells. J Biol Chem. 2005 Feb 18;280(7):6016-27. Epub 2004 Dec 1.

We found here that this recruitment was dependent on protein synthesis, because a protein synthesis inhibitor, cycloheximide, prevented the accumulation of E-cadherin.
41(0,1,1,11) Details
19604397 Hugo HJ, Wafai R, Blick T, Thompson EW, Newgreen DF: Staurosporine augments EGF-mediated EMT in PMC42-LA cells through actin depolymerisation, focal contact size reduction and Snail1 induction - a model for cross-modulation. BMC Cancer. 2009 Jul 15;9:235.

METHODS: PMC42-LA cells were treated for 72 h with 10 ng/ml EGF, 40 nM ST, or both, and assessed for expression of E-cadherin repressor genes (Snail1, Snail2, Zeb1/deltaEF1) and EMT-related genes by QRT-PCR, multiplex tandem PCR (MT-PCR) and immunofluorescence +/- cycloheximide.
8(0,0,1,3) Details
17592017 Bosco D, Rouiller DG, Halban PA: Differential expression of E-cadherin at the surface of rat beta-cells as a marker of functional heterogeneity. J Endocrinol. 2007 Jul;194(1):21-9.

Cycloheximide inhibited expression of E-cadherin at 2.8 mM glucose, but not at 16.7 mM, while depolymerization of actin by either cytochalasin B or latrunculin B increased surface E-cadherin at low glucose.
5(0,0,0,5) Details
17495535 Lee SH, Lee SJ, Kim JH, Park BJ: Chemical carcinogen, N-methyl-N'-nitro-N-nitrosoguanidine, is a specific activator of oncogenic Ras. Cell Cycle. 2007 May 15;6(10):1257-64. Epub 2007 May 6.

Activation of Erk by MNNG could not suppressed by cycloheximide and ALLN.
Moreover, MNNG could reduce the expression of E-cadherin and promote dissociation of beta-catenin from E-cadherin through oncogenic-Ras-MAPK pathway.
1(0,0,0,1) Details