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Bulik S, Peters B, Holzhutter HG: Quantifying the contribution of defective ribosomal products to antigen production: a model-based computational analysis. J Immunol. 2005 Dec 15;175(12):7957-64.
From our modeling approach, we conclude that in these experiments 1) the relative share of DRiPs in the total protein synthesis amounted to approximately 10% thus being much lower than reported so far, 2) DRiPs may become the decisive source of epitopes within an early phase after onset of the synthesis of a long-lived (e.g., virus derived) protein, and 3) inhibition of protein synthesis by the translation inhibitor cycloheximide appears to be paralleled with an instantaneous decrease of protein degradation down to approximately 1/3 of the normal value. |
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