| Name | superoxide dismutase |
|---|---|
| Synonyms | IPO B; Indophenoloxidase B; MNSOD; Manganese superoxide dismutase; Manganese containing superoxide dismutase; Mangano superoxide dismutase; Mn superoxide dismutase; Mn SOD… |
| Name | cycloheximide |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17337591 | Fernandez-Velasco M, Ruiz-Hurtado G, Hurtado O, Moro MA, Delgado C: TNF-alpha downregulates transient outward current in rat ventricular myocytes through iNOS overexpression and oxidant species generation. Am J Physiol Heart Circ Physiol. 2007 Jul;293(1):H238-45. Epub 2007 Mar 2. We have also demonstrated that the reduction of I (to) density induced by TNF-alpha was prevented by the selective inducible synthase (iNOS) inhibitor 1400-W, the protein synthesis inhibitor cycloheximide, the antioxidant and the superoxide dismutase mimetic (III) tetrakis (4- |
31(0,1,1,1) | Details |
| 16910777 | Dasgupta J, Subbaram S, Connor KM, Rodriguez AM, Tirosh O, Beckman JS, Jourd'Heuil D, Melendez JA: Manganese superoxide dismutase protects from TNF-alpha-induced apoptosis by increasing the steady-state production of H2O2. Antioxid Redox Signal. 2006 Jul-Aug;8(7-8):1295-305. |
6(0,0,0,6) | Details |
| 19563893 | Holley AK, Kiningham KK, Spitz DR, Edwards DP, Jenkins JT, Moore MR: stimulation of manganese superoxide dismutase and invasive properties in T47D human breast cancer cells. J Steroid Biochem Mol Biol. 2009 Oct;117(1-3):23-30. Epub 2009 Jun 27. Cycloheximide inhibits stimulation at the mRNA level, suggesting that induction of MnSOD mRNA depends on synthesis of protein. |
2(0,0,0,2) | Details |
| 19463099 | Lushchak OV, Nykorak NZ, Ohdate T, Inoue Y, Lushchak VI: Inactivation of genes encoding superoxide dismutase modifies yeast response to S-nitrosoglutathione-induced stress. Biochemistry. 2009 Apr;74(4):445-51. Inhibition of protein synthesis by cycloheximide did not prevent the activation of SOD, but it prevented the activation of catalase. |
2(0,0,0,2) | Details |
| 17157182 | Pardo M, Melendez JA, Tirosh O: Manganese superoxide dismutase inactivation during Fas (CD95)-mediated apoptosis in Jurkat T cells. Free Radic Biol Med. 2006 Dec 15;41(12):1795-806. Epub 2006 Sep 16. In the presence of cycloheximide, an inhibitor of protein synthesis, the rates of cell death and MnSOD degradation were accelerated. |
2(0,0,0,2) | Details |
| 15993699 | Fatima RA, Ahmad M: Certain antioxidant enzymes of Allium cepa as biomarkers for the detection of toxic heavy metals in wastewater. Sci Total Environ. 2005 Jun 15;346(1-3):256-73. In the presence of cycloheximide, all the enzymes returned to the levels of untreated controls while chloramphenicol did not have any effect on the test enzymes, thereby suggesting de novo protein synthesis of the test antioxidant enzymes in the cytosolic compartment of the cell as a result of exposure to the heavy metals. The utility of antioxidant enzymes, viz glutathione-S-transferase (GST), glutathione reductase (GR), superoxide dismutase (SOD), catalase (CAT), peroxidase (APX), peroxidase (GPX), monodehydroascorbate reductase (MDHAR) and reductase (DHAR), as biomarkers of heavy metal pollution in water was investigated using the Allium cepa (onion) system. |
1(0,0,0,1) | Details |
| 17100288 | Bailiak MM, Semchyshyn HM, Lushchak VI: [Role of catalase and superoxide dismutase in the yeast Saccharomyces cerevisiae response to peroxide in exponential phase of growth]. Ukr Biokhim Zh. 2006 Mar-Apr;78(2):79-85. The effect was cancelled by cycloheximide, an inhibitor of protein synthesis. |
2(0,0,0,2) | Details |
| 19439213 | Chen X, Choi IY, Chang TS, Noh YH, Shin CY, Wu CF, Ko KH, Kim WK: Pretreatment with interferon-gamma protects microglia from oxidative stress via up-regulation of Mn-SOD. Free Radic Biol Med. 2009 Apr 15;46(8):1204-10. Epub 2009 Feb 9. The cytoprotective effect of IFN-gamma pretreatment was abolished by the protein synthesis inhibitor cycloheximide. Among various antioxidant enzymes such as or /zinc superoxide dismutase (Mn-SOD or Cu/Zn-SOD), catalase, and peroxidase (GPx), only Mn-SOD was up-regulated in IFN-gamma-pretreated microglial cells. |
1(0,0,0,1) | Details |
| 16252307 | Meloni BP, Van Dyk D, Cole R, Knuckey NW: Proteome analysis of cortical neuronal cultures following cycloheximide, heat stress and MK801 preconditioning. Proteomics. 2005 Dec;5(18):4743-53. Six protein spots (actin, elongation factor 1-alpha 1, peptidyl-prolyl cis-transisomerase A, Cu/Zn superoxide dismutase, stathmin, tropomyosin) were differentially expressed in all three preconditioning treatments. |
1(0,0,0,1) | Details |
| 16076025 | Danielisova V, Nemethova M, Gottlieb M, Burda J: Changes of endogenous antioxidant enzymes during ischemic tolerance acquisition. Neurochem Res. 2005 Apr;30(4):559-65. The purpose of this study was to investigate the role of superoxide dismutase (SOD) and catalase (CAT) in brain ischemic tolerance induced by ischemic preconditioning. Our attempt to understand the mechanisms of increased SOD and CAT activities by application of protein synthesis inhibitor cycloheximide showed that this increase was caused by de novo synthesis of enzymes during first hours after ischemia. |
1(0,0,0,1) | Details |
| 16822952 | Basuroy S, Bhattacharya S, Tcheranova D, Qu Y, Regan RF, Leffler CW, Parfenova H: HO-2 provides endogenous protection against oxidative stress and apoptosis caused by TNF-alpha in cerebral vascular endothelial cells. Am J Physiol Cell Physiol. 2006 Nov;291(5):C897-908. Epub 2006 Jul 5. The TNF-alpha response was inhibited by superoxide dismutase and catalase suggesting apoptosis is oxidative stress related. In CMVEC from mice and newborn pigs, 15 ng/ml TNF-alpha alone, or with 10 microg/ml cycloheximide (CHX) caused apoptosis detected by nuclear translocation of p65 NF-kappaB, caspase-3 activation, DNA fragmentation, cell-cell contact destabilization, and cell detachment. |
1(0,0,0,1) | Details |
| 18339020 | Long F, Wang Y, Qi HH, Zhou X, Jin XQ: Rapid non-genomic effects of glucocorticoids on oxidative stress in a guinea pig model of asthma. Respirology. 2008 Mar;13(2):227-32. These rapid effects were not blocked by the GC receptor antagonist RU486 and/or the protein synthesis inhibitor cycloheximide. BAL fluid (BALF), trolox equivalent antioxidant capacity and lung manganese superoxide dismutase (MnSOD) activity were measured by spectrophotometry. |
1(0,0,0,1) | Details |
| 16257643 | Bayraktutan U: Coronary microvascular endothelial cell growth regulates expression of the gene encoding p22-phox. Free Radic Biol Med. 2005 Nov 15;39(10):1342-52. Epub 2005 Aug 29. Suppression of O (2)(-) availability by a cell-permeable superoxide dismutase mimetic or inhibition of NAD (P) H oxidase activity via its specific inhibitors (apocynin, diphenyleneiodinium, phenylarsine oxide, and 4-(2-aminoethyl) bezenesulfonyl or antisense p22-phox cDNA attenuated cell growth independent of changes in intracellular antioxidant levels. Inhibition of nascent protein synthesis by a translation inhibitor, cycloheximide, significantly reduced p22-phox mRNA stability in proliferating but not in confluent CMEC. |
1(0,0,0,1) | Details |
| 16378625 | Wu CC, Hsu MC, Hsieh CW, Lin JB, Lai PH, Wung BS: Upregulation of heme oxygenase-1 by via the phosphatidylinositol 3-kinase/Akt and ERK pathways. Life Sci. 2006 May 15;78(25):2889-97. Epub 2005 Dec 27. Furthermore, -mediated HO-1 induction was abrogated in the presence of actinomycin D and cycloheximide, indicating that this upregulation of HO-1 occurred at the transcriptional level. The inhibition of intracellular ROS production by (NAC), (GSH), superoxide dismutase (SOD), catalase and the mitochondrial complex I inhibitor, rotenone, results in a decrease in -dependent HO-1 expression. |
1(0,0,0,1) | Details |
| 16809935 | Riva DA, de Molina MC, Rocchetta I, Gerhardt E, Coulombie FC, Mersich SE: Oxidative stress in vero cells infected with vesicular stomatitis virus. Intervirology. 2006;49(5):294-8. Epub 2006 Jun 29. Further, superoxide dismutases, which occupy the first step within the antioxidant enzyme cascade, also exhibit a rise in VSV-infected Vero cells, at different MOI. LP levels exhibited a rise at different times post infection, according to the multiplicity of infection (MOI), while the presence of cycloheximide determined a reduction on LP. |
1(0,0,0,1) | Details |
| 19873875 | Lushchak OV, Lushchak VI: Possible pathways involved in activation of catalase and superoxide dismutase with sodium nitroprusside in yeast Saccharomyces cerevisiae. Ukr Biokhim Zh. 2009 Mar-Apr;81(2):34-9. Using inhibitors of mRNA (actinomycin D) and protein (cycloheximide) synthesis, the strain deficient in Yap1p, a master regulator coordinating yeast adaptive response to oxidative stress, we have found that these enzymes are up-regulated via synthesis of new molecules at transcription and translation levels. |
1(0,0,0,1) | Details |
| 18647484 | Lushchak OV, Lushchak VI: Sodium nitroprusside induces mild oxidative stress in Saccharomyces cerevisiae. Redox Rep. 2008;13(4):144-52. Yeast incubation with SNP increased the activities of catalase and superoxide dismutase. Cycloheximide, an inhibitor of translation, blocked SNP-induced catalase activation, but not SOD activation. |
1(0,0,0,1) | Details |
| 15839099 | Angelova MB, Pashova SB, Spasova BK, Vassilev SV, Slokoska LS: Oxidative stress response of filamentous fungi induced by peroxide and paraquat. Mycol Res. 2005 Feb;109(Pt 2):150-8. Cell responses against both and peroxide stresses include enhanced expression of superoxide dismutase (SOD) and catalase, however, the extent was different: treatment with PQ increased mainly SOD, whereas exogenous H2O2 led to enhanced catalase. The activation of antioxidant enzyme defence was blocked by the translation inhibitor, cycloheximide, suggesting that there was de novo enzyme synthesis. |
1(0,0,0,1) | Details |
| 15819811 | Ajamieh HH, Berlanga J, Merino N, Sanchez GM, Carmona AM, Cepero SM, Giuliani A, Re L, Leon OS: Role of protein synthesis in the protection conferred by ozone-oxidative-preconditioning in hepatic ischaemia/reperfusion. Transpl Int. 2005 May;18(5):604-12. Rats were treated with cycloheximide (CHX) in order to promote protein synthesis inhibition after OzoneOP treatment. Plasma transaminases, malondialdehyde and 4-hydroxyalkenals and morphological characteristics were measured as an index of hepatocellular damage; Cu/Zn-superoxide dismutase (SOD), Mn-SOD, catalase, total hydroperoxides and levels as markers of endogenous antioxidant system. |
1(0,0,0,1) | Details |
| 18270435 | Tanaka S, Takayanagi N, Murasawa K, Ishii C, Inoue H: Genetic and molecular analysis of the temperature-sensitive mutant un-17 carrying a mutation in the gene encoding poly (A)-polymerase in Neurospora crassa. Genes Genet Syst. 2007 Dec;82(6):447-54. This ts phenotype is suppressed by addition of cycloheximide or in some conditions of growth repression. Even at the permissive temperature, it shows a female sterile phenotype and is deficient in production of exocellular superoxide dismutase SOD4 (EC 1.15.1.1). |
1(0,0,0,1) | Details |
| 19017469 | Lushchak OV, Lushchak VI: Catalase modifies yeast Saccharomyces cerevisiae response towards S-nitrosoglutathione-induced stress. Redox Rep. 2008;13(6):283-91. Incubation of yeast with GSNO increased the activities of both superoxide dismutase (SOD) and catalase. Pre-incubation with cycloheximide prevented the activation of catalase, but not SOD. |
1(0,0,0,1) | Details |
| 17641050 | Wang HL, Akinci IO, Baker CM, Urich D, Bellmeyer A, Jain M, Chandel NS, Mutlu GM, Budinger GR: The intrinsic apoptotic pathway is required for lipopolysaccharide-induced lung endothelial cell death. J Immunol. 2007 Aug 1;179(3):1834-41. We sought to determine whether LPS and cycloheximide-induced cell death in human lung microvascular endothelial cells (HmVECs) was dependent upon activation of the intrinsic apoptotic pathway and the generation of reactive species. |
0(0,0,0,0) | Details |
| 16956375 | Leak RK, Liou AK, Zigmond MJ: Effect of sublethal on the response to subsequent oxidative stress in dopaminergic cells: evidence for preconditioning. J Neurochem. 2006 Nov;99(4):1151-63. Epub 2006 Sep 4. The antioxidant, N-acetyl (20 mM), when applied during preconditioning, abolished protection, as did the protein synthesis inhibitor, cycloheximide (0.2 microM). |
0(0,0,0,0) | Details |
| 17302992 | Wang ZJ, Liang CL, Li GM, Yu CY, Yin M: protects primary cultured cortical neurons against oxidative stress. Acta Pharmacol Sin. 2007 Mar;28(3):315-26. Endogenous antioxidant enzymes activity [superoxide dismutases (SOD), peroxidase (GSH-Px), and catalase (CAT)] and lipid peroxidation in cultured cortical neurons were evaluated using commercial kits. {3-[1 (p-chlorobenzyl)- 5-(isopropyl)-3-t-butylthiondol-2-yl]-2,2-dimethylpropanoic acid, Na} [MK886; 5 micromol/L; a noncompetitive inhibitor of proliferator-activated receptor (PPAR) alpha], bisphenol A diglycidyl ether (BADGE; 100 micromol/L; an antagonist of PPAR gamma), and cycloheximide (CHX; 30 micromol/L, an inhibitor of protein synthesis) were tested for their effects on the neuroprotection afforded by |
31(0,1,1,1) | Details |