Protein Information

Name PIN1
Synonyms DOD; PIN 1; PIN1; PPIase Pin1; Peptidyl prolyl cis trans isomerase NIMA interacting 1; Prolyl isomerase; Rotamase Pin1; UBL 5…

Compound Information

Name cycloheximide
CAS

Reference List

PubMed Abstract RScore(About this table)
19545424 Liu T, Schneider RA, Shah V, Huang Y, Likhotvorik RI, Keshvara L, Hoyt DG: Protein Never in Mitosis Gene A Interacting-1 regulates calpain activity and the degradation of cyclooxygenase-2 in endothelial cells. J Inflamm. 2009 Jun 22;6:20.

Cells were treated with LPS/IFN, calpain inhibitors (carbobenzoxy-valinyl-phenylalaninal (zVF), PD150606), cycloheximide and COX inhibitors to determine the effect of PIN1 depletion on COX-2 and calpain.
170(2,2,2,10) Details
18650263 Liu T, Huang Y, Likhotvorik RI, Keshvara L, Hoyt DG: Protein Never in Mitosis Gene A Interacting-1 (PIN1) regulates degradation of inducible nitric oxide synthase in endothelial cells. Am J Physiol Cell Physiol. 2008 Sep;295(3):C819-27. Epub 2008 Jul 23.

Consistent with posttranscriptional action, knockdown of PIN1 increased the stability of iNOS protein in cycloheximide-treated cells.
12(0,0,1,7) Details