Protein Information

Name Aa nat
Synonyms AA NAT; AANAT; AANAT protein; Aralkylamine N acetyltransferase; Arylalkylamine N acetyltransferase; SNAT; Serotonin N acetyltransferase; Serotonin acetylase…

Compound Information

Name cycloheximide
CAS

Reference List

PubMed Abstract RScore(About this table)
16099857 Terriff DL, Chik CL, Price DM, Ho AK: Proteasomal proteolysis in the adrenergic induction of arylalkylamine-N-acetyltransferase in rat pinealocytes. Endocrinology. 2005 Nov;146(11):4795-803. Epub 2005 Aug 11.

This possibility was also supported by the finding that the inhibitory effect of c-lact on NE-induced aa-nat induction was markedly reduced by cycloheximide, a protein synthesis inhibitor.
87(1,1,1,7) Details
17014691 Fernandes PA, Cecon E, Markus RP, Ferreira ZS: Effect of TNF-alpha on the melatonin synthetic pathway in the rat pineal gland: basis for a 'feedback' of the immune response on circadian timing. J Pineal Res. 2006 Nov;41(4):344-50.

In fact, a protein (s) transcribed, later on, as shown by cycloheximide, was responsible for the reversal of the inhibition of Aa-nat transcription.
84(1,1,1,4) Details
16887909 Sinitskaya N, Salingre A, Klosen P, Revel FG, Pevet P, Simonneaux V: Differential expression of activator protein-1 proteins in the pineal gland of Syrian hamster and rat may explain species diversity in arylalkylamine N-acetyltransferase gene expression. Endocrinology. 2006 Nov;147(11):5052-60. Epub 2006 Aug 3.

Indeed, early-night administration of a protein synthesis inhibitor (cycloheximide) markedly decreased AA-NAT mRNA levels in Syrian hamster.
6(0,0,0,6) Details
19470703 Kanyo R, Price DM, Chik CL, Ho AK: Salt-inducible kinase 1 in the rat pinealocyte: adrenergic regulation and role in arylalkylamine N-acetyltransferase gene transcription. Endocrinology. 2009 Sep;150(9):4221-30. Epub 2009 May 21.

6(0,0,0,6) Details
16687308 Simonneaux V, Sinitskaya N, Salingre A, Garidou ML, Pevet P: Rat and Syrian hamster: two models for the regulation of AANAT gene expression. Chronobiol Int. 2006;23(1-2):351-9.

Interestingly, injection of the protein synthesis inhibitor cycloheximide before, but not after, the c-FOS/c-JUN peak markedly reduces Aanat mRNA levels.
4(0,0,0,4) Details