Protein Information

Name Glut 4
Synonyms GLUT 4; GLUT4; Glucose transporter 4; SLC2A4; Solute carrier family 2 member 4; Glucose transporter 4s; Solute carrier family 2 member 4s

Compound Information

Name cycloheximide
CAS

Reference List

PubMed Abstract RScore(About this table)
15707762 Anandharajan R, Pathmanathan K, Shankernarayanan NP, Vishwakarma RA, Balakrishnan A: Upregulation of Glut-4 and PPAR gamma by an isoflavone from Pterocarpus marsupium on L6 myotubes: a possible mechanism of action. J Ethnopharmacol. 2005 Feb 28;97(2):253-60. Epub 2005 Jan 13.

The inhibitory effect of cycloheximide on Pterocarpus marsupium methanolic extract and Pterocarpus marsupium isoflavone-mediated glucose uptake suggested that new protein synthesis is required for elevated Glut-4 protein expression.
84(1,1,1,4) Details
16716914 Anandharajan R, Jaiganesh S, Shankernarayanan NP, Viswakarma RA, Balakrishnan A: In vitro glucose uptake activity of Aegles marmelos and Syzygium cumini by activation of Glut-4, PI3 kinase and PPARgamma in L6 myotubes. Phytomedicine. 2006 Jun;13(6):434-41. Epub 2005 Nov 2.

The inhibitory effect of cycloheximide on A. marmelos- and S. cumini-mediated glucose uptake suggested that new protein synthesis is required for the elevated glucose transport.
3(0,0,0,3) Details
17015939 Purintrapiban J, Suttajit M, Forsberg NE: Differential activation of glucose transport in cultured muscle cells by polyphenolic compounds from Canna indica L. Biol Pharm Bull. 2006 Oct;29(10):1995-8.

The CI extract increased the amount of glucose transporter isoforms 1 (GLUT1) and 4 (GLUT4) at the cell surface and enhanced expression of GLUT1 protein.
Cycloheximide treatment almost completely reversed CI-induced 2-DG uptake to the basal level.
1(0,0,0,1) Details
15632169 MacAulay K, Blair AS, Hajduch E, Terashima T, Baba O, Sutherland C, Hundal HS: Constitutive activation of GSK3 down-regulates glycogen synthase abundance and glycogen deposition in rat skeletal muscle cells. J Biol Chem. 2005 Mar 11;280(10):9509-18. Epub 2005 Jan 4.


However, the increase in GS protein in undifferentiated myoblasts or that seen following incubation of cells expressing GSK3S9A with GSK3 inhibitors was blocked by cycloheximide suggesting that GSK3 influences GS abundance possibly via control of mRNA translation.
0(0,0,0,0) Details