| Name | H:quinone oxidoreductase |
|---|---|
| Synonyms | Diaphorase; DHQU; DIA 4; DIA4; DT diaphorase; DTD; Diaphorase (NADH/NADPH); Diaphorase (NADH/NADPH) (cytochrome b 5 reductase)… |
| Name | cycloheximide |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18388957 | Garate M, Wong RP, Campos EI, Wang Y, Li G: NAD (P) H quinone oxidoreductase 1 inhibits the proteasomal degradation of the tumour suppressor p33 (ING1b). EMBO Rep. 2008 Jun;9(6):576-81. Epub 2008 Apr 4. We found that p33 (ING1b) is degraded in the 20S proteasome and that NAD (P) H quinone oxidoreductase 1 (NQO1), an oxidoreductase previously shown to modulate the degradation of p53 in the 20S proteasome, inhibits the degradation of p33 (ING1b). |
2(0,0,0,2) | Details |
| 17189831 | Warabi E, Takabe W, Minami T, Inoue K, Itoh K, Yamamoto M, Ishii T, Kodama T, Noguchi N: Shear stress stabilizes NF-E2-related factor 2 and induces antioxidant genes in endothelial cells: role of reactive / species. Free Radic Biol Med. 2007 Jan 15;42(2):260-9. Epub 2006 Oct 20. We have previously reported that antioxidant response element (ARE)-regulated genes, such as heme oxygenase 1 (HO-1), sequestosome 1 (SQSTM1), and NAD (P) H quinone oxidoreductase 1 (NQO1), are induced in human umbilical vein endothelial cells (HUVEC) upon exposure to laminar shear stress. Nrf2 was rapidly degraded in cells treated with cycloheximide under static conditions, but shear stress decreased the rate of Nrf2 degradation. |
2(0,0,0,2) | Details |
| 19657853 | Dong GZ, Youn H, Park MT, Oh ET, Park KH, Song CW, Choi EK, Park HJ: Heat shock increases expression of NAD (P) H:quinone oxidoreductase (NQO1), mediator of beta-lapachone cytotoxicity, by increasing NQO1 gene activity and via Hsp70-mediated stabilisation of NQO1 protein. Int J Hyperthermia. 2009;25(6):477-87. |
11(0,0,0,11) | Details |
| 16243960 | Korashy HM, El-Kadi AO: Transcriptional regulation of the NAD (P) H:quinone oxidoreductase 1 and glutathione S-transferase ya genes by mercury, lead, and Drug Metab Dispos. 2006 Jan;34(1):152-65. Epub 2005 Oct 21. The protein synthesis inhibitor cycloheximide significantly inhibited metal-mediated induction of Nqo1 and Gst ya mRNAs, which coincided with a decrease in the nuclear factor erythroid 2-related factor 2 (Nrf2) protein expression, implying the requirement of Nrf2 protein synthesis for the induction of these genes. |
2(0,0,0,2) | Details |
| 18474416 | Elbekai RH, El-Kadi AO: Arsenite and cadmium, but not induce NAD (P) H:quinone oxidoreductase 1 through transcriptional mechanisms, in spite of post-transcriptional modifications. Toxicol In Vitro. 2008 Aug;22(5):1184-90. Epub 2008 Mar 31. NAD (P) H:quinone oxidoreductase (Nqo1)-mediated detoxification of quinones plays a critical role in cancer prevention. Furthermore, the protein synthesis inhibitor cycloheximide decreased Nqo1 mRNA induction, suggesting a role for a labile protein in the transcriptional induction of Nqo1 mRNA by metals. |
1(0,0,0,1) | Details |
| 17916901 | Keum YS, Chang PP, Kwon KH, Yuan X, Li W, Hu L, Kong AN: 3-Morpholinopropyl isothiocyanate is a novel synthetic isothiocyanate that strongly induces the antioxidant response element-dependent Nrf2-mediated detoxifying/antioxidant enzymes in vitro and in vivo. Carcinogenesis. 2008 Mar;29(3):594-9. Epub 2007 Oct 4. Using chemical inhibitors of protein synthesis (cycloheximide) and 26S proteosomal degradation (MG-132), we observed that the induction of Nrf2 protein by 3MP-ITC appeared to be post-translationally regulated. 3MP-ITC activated ERK1/2 and JNK1/2 and the activation of antioxidant response element (ARE) by 3MP-ITC was significantly attenuated by chemical inhibition of PKC and PI3K signaling pathways in HepG2C8 cells. |
0(0,0,0,0) | Details |
| 19897490 | Kaspar JW, Jaiswal AK: Antioxidant-induced phosphorylation of 486 leads to rapid nuclear export of Bach1 that allows Nrf2 to bind to the antioxidant response element and activate defensive gene expression. J Biol Chem. 2010 Jan 1;285(1):153-62. Epub 2009 Nov 6. Bach1 levels inside the nucleus returned to normal at 4 h after antioxidant treatment in the absence but not in the presence of protein synthesis inhibitor cycloheximide. |
0(0,0,0,0) | Details |