Protein Information

Name aquaporins (protein family or complex)
Synonyms aquaporin; aquaporins

Compound Information

Name cycloheximide
CAS

Reference List

PubMed Abstract RScore(About this table)
17114274 Cochard H, Venisse JS, Barigah TS, Brunel N, Herbette S, Guilliot A, Tyree MT, Sakr S: Putative role of aquaporins in variable hydraulic conductance of leaves in response to light. Plant Physiol. 2007 Jan;143(1):122-33. Epub 2006 Nov 17.

Light responses of K (leaf) and aquaporin transcripts were reversible and inhibited by cycloheximide, indicating the importance of de novo protein biosynthesis in this process.
85(1,1,1,5) Details
19969533 Sadok W, Sinclair TR: Transpiration response of 'slow-wilting' and commercial soybean (Glycine max (L.) Merr.) genotypes to three aquaporin inhibitors. J Exp Bot. 2010 Mar;61(3):821-9. Epub 2009 Dec 6.

Three AQP inhibitors were tested: cycloheximide (CHX, a de novo synthesis inhibitor), HgCl (2), and AgNO (3).
2(0,0,0,2) Details
18717646 Flamenco P, Galizia L, Rivarola V, Fernandez J, Ford P, Capurro C: Role of AQP2 during apoptosis in cortical collecting duct cells. Biol Cell. 2009 Apr;101(4):237-50.

It was recently reported that in some systems this water movement is mediated via specific water channels (aquaporins).
RESULTS: Apoptosis was induced by incubating cells with a hypertonic solution or with cycloheximide in two cortical collecting duct cell lines: one not expressing aquaporins and the other stably transfected with aquaporin-2.
1(0,0,0,1) Details
18406487 Morishima T, Aoyama M, Iida Y, Yamamoto N, Hirate H, Arima H, Fujita Y, Sasano H, Tsuda T, Katsuya H, Asai K, Sobue K: Lactic acid increases aquaporin 4 expression on the cell membrane of cultured rat astrocytes. Neurosci Res. 2008 May;61(1):18-26. Epub 2008 Jan 17.

The water channel protein aquaporin (AQP) may play roles in the homeostasis of water content in the brain and brain edema.
Under the conditions of de novo protein synthesis inhibition with cycloheximide, lactic acid increased the AQP4 expression level.
1(0,0,0,1) Details