| Name | glucagon like peptide 2 |
|---|---|
| Synonyms | GCG; GLP 1; GLP1; GLP 2; GLP2; GRPP; Glicentin related polypeptide; Glucagon… |
| Name | cycloheximide |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18829546 | Koehler JA, Harper W, Barnard M, Yusta B, Drucker DJ: Glucagon-like peptide-2 does not modify the growth or survival of murine or human intestinal tumor cells. Cancer Res. 2008 Oct 1;68(19):7897-904. Glucagon-like peptide-2 (GLP-2) secreted from enteroendocrine cells exerts proabsorptive, regenerative, and cytoprotective actions in the normal and injured gut epithelium. However, GLP-2 did not stimulate cell growth or attenuate cycloheximide-, LY294002-, indomethacin-, or chemotherapy-induced cytotoxicity in vitro. |
1(0,0,0,1) | Details |
| 19193945 | Soria LR, Gradilone SA, Larocca MC, Marinelli RA: Glucagon induces the gene expression of aquaporin-8 but not that of aquaporin-9 water channels in the rat hepatocyte. Am J Physiol Regul Integr Comp Physiol. 2009 Apr;296(4):R1274-81. Epub 2009 Feb 4. Cycloheximide also showed no effect, suggesting that glucagon-induced AQP8 expression does not depend on protein synthesis but rather on protein degradation. Glucagon stimulates the vesicle trafficking of aquaporin-8 (AQP8) water channels to the rat hepatocyte canalicular membranes, a process thought to be relevant to glucagon-induced bile secretion. |
8(0,0,0,8) | Details |
| 18762908 | Gonzalez M, Boer U, Dickel C, Quentin T, Cierny I, Oetjen E, Knepel W: Loss of insulin-induced inhibition of glucagon gene transcription in hamster pancreatic islet alpha cells by long-term insulin exposure. Diabetologia. 2008 Nov;51(11):2012-21. Epub 2008 Sep 2. Cycloheximide and in vivo labelling experiments attributed IR downregulation to enhanced degradation. |
7(0,0,0,7) | Details |
| 19398497 | Kang JH, Chang SY, Jang HJ, Kim DB, Ryu GR, Ko SH, Jeong IK, Jo YH, Kim MJ: Exendin-4 inhibits interleukin-1beta-induced iNOS expression at the protein level, but not at the transcriptional and posttranscriptional levels, in RINm5F beta-cells. J Endocrinol. 2009 Jul;202(1):65-75. Epub 2009 Apr 27. Additionally, the cycloheximide chase study demonstrated that EX-4 significantly accelerated iNOS protein degradation. Meanwhile, glucagon-like peptide-1 (GLP-1) and its potent analog exendin-4 (EX-4) were well known for beta-cell proliferation. |
1(0,0,0,1) | Details |
| 16644694 | Koehler JA, Drucker DJ: Activation of glucagon-like peptide-1 receptor signaling does not modify the growth or apoptosis of human pancreatic cancer cells. Diabetes. 2006 May;55(5):1369-79. Glucagon-like peptide (GLP)-1 promotes beta-cell proliferation and survival through stimulation of its specific G-protein-coupled receptor; however, the potential for GLP-1 receptor (GLP-1R) agonists to promote growth and proliferation of human pancreatic-derived cells remains poorly understood. Ex-4 did not modulate the proliferation of these cell lines in vitro and did not inhibit apoptosis after exposure of cells to cytotoxic agents such as cycloheximide, indomethacin, LY294002, or cyclopamine. |
1(0,0,0,1) | Details |
| 15893582 | Confaloni A, Crestini A, Albani D, Piscopo P, Campeggi LM, Terreni L, Tartaglia M, Forloni G: Rat nicastrin gene: cDNA isolation, mRNA variants and expression pattern analysis. Brain Res Mol Brain Res. 2005 May 20;136(1-2):12-22. Epub 2005 Mar 16. Then, nicastrin has a central role in presenilin-mediated processing of beta-amyloid precursor protein and in some aspects of Notch/glp-1 signaling in vivo. |
1(0,0,0,1) | Details |