| Name | chemokine receptor (protein family or complex) |
|---|---|
| Synonyms | chemokine receptor; chemokine receptors |
| Name | cycloheximide |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18252865 | Happel C, Steele AD, Finley MJ, Kutzler MA, Rogers TJ: DAMGO-induced expression of chemokines and chemokine receptors: the role of TGF-beta1. J Leukoc Biol. 2008 Apr;83(4):956-63. Epub 2008 Feb 5. Similarly, pretreatment with cycloheximide prevented CCL5 or CXCR4 mRNA expression, consistent with the observation that DAMGO induction of chemokine and chemokine receptor expression requires newly synthesized TGF-beta1 protein. |
34(0,1,1,4) | Details |
| 17389578 | Morrison PT, Thomas LH, Sharland M, Friedland JS: RSV-infected airway epithelial cells cause biphasic up-regulation of CCR1 expression on human monocytes. J Leukoc Biol. 2007 Jun;81(6):1487-95. Epub 2007 Mar 27. RSV-infected epithelial cells secrete many cytokines and chemokines, but little is known about regulation of chemokine receptors on target cells. Intracellular staining revealed little internal sequestration of CCR1 protein, and CCR1 up-regulation was inhibited by actinomycin D and cycloheximide, indicating that both waves of RSV-CM-induced surface CCR1 expression were dependent on de novo transcription and protein synthesis. |
1(0,0,0,1) | Details |
| 20178462 | Simons D, Grieb G, Hristov M, Pallua N, Weber C, Bernhagen J, Steffens G: Hypoxia-induced endothelial secretion of macrophage migration inhibitory factor and role in endothelial progenitor cell recruitment. J Cell Mol Med. 2010 Feb 22. Abstract Macrophage migration inhibitory factor (MIF) is a pleiotropic inflammatory cytokine that was recently identified as a non-cognate ligand of the chemokine receptors CXCR2 and CXCR4. Early hypoxia-triggered MIF secretion was not inhibited by cycloheximide and echinomycin, inhibitors of general and HIF-1alpha-induced protein synthesis, respectively. |
1(0,0,0,1) | Details |
| 17405813 | Neel NF, Lapierre LA, Goldenring JR, Richmond A: RhoB plays an essential role in CXCR2 sorting decisions. J Cell Sci. 2007 May 1;120(Pt 9):1559-71. Epub 2007 Apr 3. The CXCR2 chemokine receptor is a G-protein-coupled receptor that undergoes clathrin-mediated endocytosis upon ligand binding. |
1(0,0,0,1) | Details |
| 18337562 | Murooka TT, Rahbar R, Platanias LC, Fish EN: CCL5-mediated T-cell chemotaxis involves the initiation of mRNA translation through mTOR/4E-BP1. Blood. 2008 May 15;111(10):4892-901. Epub 2008 Mar 12. The multistep, coordinated process of T-cell chemotaxis requires chemokines, and their chemokine receptors, to invoke signaling events to direct cell migration. Cycloheximide, but not actinomycin D, significantly reduced chemotaxis, suggesting a possible role for mRNA translation in T-cell migration. |
1(0,0,0,1) | Details |
| 17425429 | Huang Y, Huang X, Zhang J, Gui J, Zhang Q: Subcellular localization and characterization of G protein-coupled receptor homolog from lymphocystis disease virus isolated in China. Viral Immunol. 2007 Spring;20(1):150-9. Quantitative analysis of apoptotic cells indicated that a considerable decrease in the apoptotic fraction of cells expressing GPCR, compared with the control cells, was detected after exposure to ActD and cycloheximide. LCDV-C GPCR encoded a 325 amino acid peptide, containing a typical seven-transmembrane domain characteristic of the chemokine receptors and a conserved DRY motif that is usually essential for receptor activation. |
1(0,0,0,1) | Details |