Protein Information

Name cytochrome c
Synonyms CYC; CYCS; Cytochrome C; HCS; Cytochrome Cs

Compound Information

Name copper sulfate
CAS sulfuric acid copper(2+) salt (1:1)

Reference List

PubMed Abstract RScore(About this table)
12953577 Jia Y, Zheng X, Hu J: [Interaction between the metal ion in the active site of cytochrome C and copper sulfate by ultraviolet spectroscopy]. Guang Pu Xue Yu Guang Pu Fen Xi. 2001 Feb;21(1):54-6.

As a result, part of the metal ion Fe (II) in Fecyt-C was replaced by Cu (II) and the corresponding cytochrome C derivatives Cucyt-C were produced, in addition, the interaction was increased with amount of copper sulfate added.
144(1,3,3,4) Details
216232 Kassabova T, Russanov E: Decorporation of copper from liver subcellular fractions after alimentary loading of rats. Acta Physiol Pharmacol Bulg. 1978;4(2):13-9.

Subcellular copper distribution was studied after single alimentary loading of rats with copper sulfate and after 2- and 4-day spontaneous decorporation of the metal.
The activities of rotenone-sensitive NADH-cytochrome c reductase, succinate-cytochrome c reductase and cytochrome oxidase were inhibited by copper treatment but after a 4-day decorporation they became normal.
2(0,0,0,2) Details
17239413 Chen TG, Chen TL, Chang HC, Tai YT, Cherng YG, Chang YT, Chen RM: Oxidized low-density lipoprotein induces apoptotic insults to mouse cerebral endothelial cells via a Bax-mitochondria-caspase protease pathway. Toxicol Appl Pharmacol. 2007 Feb 15;219(1):42-53. Epub 2006 Dec 6.

Exposure of mouse CECs to oxLDL decreased the amounts of mitochondrial cytochrome c, but enhanced cytosolic cytochrome c levels.
Mouse CECs were isolated from brain tissues and identified by immunocytochemical staining of vimentin and Factor VIII. oxLDL was prepared from LDL oxidation by copper sulfate.
2(0,0,0,2) Details
2996807 Hartmann HJ, Gartner A, Weser U: Copper dependent control of the enzymic and phagocyte induced degradation of some biopolymers, a possible link to systemic inflammation. Clin Chim Acta. 1985 Oct 31;152(1-2):95-103.


Furthermore, PMN cell induced bleaching of cytochrome c was also affected in the presence of both CuSO4 and thionein-copper.
1(0,0,0,1) Details
16261369 Fujimori T, Yamada S, Yasui H, Sakurai H, In Y, Ishida T: Orally active antioxidative copper (II) aspirinate: synthesis, structure characterization, superoxide scavenging activity, and in vitro and in vivo antioxidative evaluations. J Biol Inorg Chem. 2005 Dec;10(8):831-41. Epub 2005 Oct 28.


Its SOD-mimetic activity was determined using cytochrome c, electron spin resonance (ESR) spectroscopy, and ESR spin trap methods.
1(0,0,0,1) Details
17216433 Ou HC, Chou FP, Sheu WH, Hsu SL, Lee WJ: Protective effects of magnolol against oxidized LDL-induced apoptosis in endothelial cells. Arch Toxicol. 2007 Jun;81(6):421-32. Epub 2007 Jan 11.


Furthermore, several apoptotic signaling pathways which showed NF-kappaB activation, increased cytosolic calcium, alteration of mitochondrial membrane potential, cytochrome c release and activation of caspase 3 were also investigated.
1(0,0,0,1) Details
2540067 Simpson JA, Smith SE, Dean RT: Scavenging by alginate of free radicals released by macrophages. . Free Radic Biol Med. 1989;6(4):347-53.


We have found that purified bacterial alginate scavenges free radicals released by triggered macrophages as detected by lucigenin amplified chemiluminescence (CL) and reduction of cytochrome c.
1(0,0,0,1) Details